12BM image
Deposition Date 2026-03-25
Release Date 2026-07-01
Last Version Date 2026-07-01
Entry Detail
PDB ID:
12BM
Keywords:
HYDROLASE
Title:
Human 19S proteasome bound to TXNL1 PITH domain state 2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.89 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
12BM validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC2
Chain IDs:A
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P35998 Pfam ID:PF21236, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC1
Chain IDs:B
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62191 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC5
Chain IDs:C
Chain Length:406
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62195 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC4
Chain IDs:D
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P43686 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S protease regulatory subun
Gene (Uniprot):PSMC6
Chain IDs:E
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62333 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome regulatory sub
Gene (Uniprot):PSMC3
Chain IDs:F
Chain Length:908
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P17980 Pfam ID:PF16450, PF00004, PF17862
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD1
Chain IDs:G (auth: U)
Chain Length:953
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q99460 Pfam ID:PF21505, PF01851, PF13646, PF18004 EC:5.6.1.5
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD3
Chain IDs:H (auth: V)
Chain Length:534
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43242 Pfam ID:PF25573, PF01399, PF08375
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RPN5
Gene (Uniprot):PSMD12
Chain IDs:I (auth: W)
Chain Length:456
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00232 Pfam ID:PF22241, PF01399, PF18098
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD11
Chain IDs:J (auth: X)
Chain Length:422
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00231 Pfam ID:PF18055, PF01399, PF18503
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD6
Chain IDs:K (auth: Y)
Chain Length:389
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q15008 Pfam ID:PF10602, PF01399, PF21154
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD7
Chain IDs:L (auth: Z)
Chain Length:324
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P51665 Pfam ID:PF01398, PF13012
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD13
Chain IDs:M (auth: a)
Chain Length:433
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q9UNM6 Pfam ID:PF22037, PF01399
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RPN10
Gene (Uniprot):PSMD4
Chain IDs:N (auth: b)
Chain Length:440
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P55036 Pfam ID:PF13519, PF02809
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD14
Chain IDs:O (auth: c)
Chain Length:406
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O00487 Pfam ID:PF01398, PF23594 EC:3.4.19.-
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD8
Chain IDs:P (auth: d)
Chain Length:350
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P48556 Pfam ID:PF10075
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome complex subuni
Gene (Uniprot):SEM1
Chain IDs:Q (auth: e)
Chain Length:70
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P60896 Pfam ID:PF05160
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:26S proteasome non-ATPase reg
Gene (Uniprot):PSMD2
Chain IDs:R (auth: f)
Chain Length:908
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q13200 Pfam ID:PF17781, PF01851, PF18051
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Thioredoxin-like protein 1
Gene (Uniprot):TXNL1
Chain IDs:S (auth: g)
Chain Length:289
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O43396 Pfam ID:PF00085, PF06201
Ligand Molecules
ADP
AGS
MG
ZN
Primary Citation
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy
To Be Published ? ? ? (?)
Primary Citation of related structures
12BM
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