12AP image
Deposition Date 2026-03-23
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
12AP
Keywords:
PROTEIN FIBRIL
Title:
Cryo-EM structure of alpha-synuclein filaments (singlet) from Parkinson's disease with A53T mutation in SNCA
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.10 Å
Aggregation State:
FILAMENT
Reconstruction Method:
HELICAL
12AP validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Alpha-synuclein
Gene (Uniprot):SNCA
Chain IDs:A
Chain Length:140
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P37840 Pfam ID:PF01387
Polymer Type:polypeptide(L)
Molecule:island B
Chain IDs:B
Chain Length:9
Number of Molecules:1
Biological Source:Homo sapiens
Primary Citation
Cryo-EM structure of alpha-synuclein filaments (singlet) from Parkinson's disease with A53T mutation in SNCA
To Be Published ? ? ? (?)
Primary Citation of related structures
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