ISDA: 12AI

Deposition Date 2026-03-23

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

12AI

Keywords:

MEMBRANE PROTEIN

Title:

Structure of mammalian Type 2 Inositol 1,4,5-trisphosphate receptor (IP3R2) in the presence of IP3/Ca2+/ATP

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.64 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Inositol 1,4,5-trisphosphate-
Gene (Uniprot):Itpr2
Chain IDs:A, B, C, D
Chain Length:2701
Number of Molecules:4
Biological Source:Mus musculus

UniProt ID:Q9Z329 Pfam ID:PF08709, PF02815, PF01365, PF08454, PF00520

Ligand Molecules

ATP

I3P

PLX

Primary Citation

Cryo-EM insights into isoform-specific properties of the IP3R2 channel

Baker, M.R, Lin, X, Fan, G, Martinez-Chavez, A, Wagner, L.E, Malik, S, Allison, T, Bell, B, Seryshev, A.B, Cordero-Morales, J, Baker, M.L, Yule, D.I, Serysheva, I.I.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-75806-y

Primary Citation of related structures

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