ISDA: 12AF

Deposition Date 2026-03-22

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

12AF

Keywords:

VIRAL PROTEIN

Title:

Crystal Structure of SARS-CoV-2 Mpro with UM-067

Biological Source:

Source Organism(s):

Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.87 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:3C-like proteinase nsp5
Gene (Uniprot):rep
Chain IDs:A
Chain Length:306
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTD1 Pfam ID:PF05409 EC:2.7.7.48

Ligand Molecules

A1DA8

GOL

Primary Citation

Crystal Structure of SARS-CoV-2 Mpro with UM-067

Shaqra, A.M, Adnan, S.F.Z, Lee, L.T, Iyer, V, Jung, K, Intravaia, L.E, Kaur, J, Schiffer, C.A.Show

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