ISDA: 11ZW

Deposition Date 2026-03-21

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

11ZW

Keywords:

VIRAL PROTEIN

Title:

Structure of the Porcine deltacoronavirus (PDCoV) receptor-binding domain bound to the RBD minibinder 11, the PD3 Fab, and the Kappa light chain nanobody

Biological Source:

Source Organism(s):

Porcine deltacoronavirus (Taxon ID: 1586324)
synthetic construct (Taxon ID: 32630)
Mus musculus (Taxon ID: 10090)
Lama glama (Taxon ID: 9844)

Expression System(s):

Homo sapiens, Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.80 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PDCoV IL121_2014 receptor bin
Gene (Uniprot):PTPRS, S
Chain IDs:A
Chain Length:175
Number of Molecules:1
Biological Source:Porcine deltacoronavirus

UniProt ID:F1NWE3,W8Q9Y7

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:RBD minibinder 11
Chain IDs:B
Chain Length:176
Number of Molecules:1
Biological Source:synthetic construct

UniProt ID:11ZW

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PD3 Fab fragment heavy chain
Chain IDs:C (auth: H)
Chain Length:261
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:11ZW

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:PD3 Fab fragment light chain
Chain IDs:D (auth: L)
Chain Length:238
Number of Molecules:1
Biological Source:Mus musculus

UniProt ID:11ZW

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Kappa light chain nanobody
Chain IDs:E (auth: N)
Chain Length:159
Number of Molecules:1
Biological Source:Lama glama

UniProt ID:11ZW

Primary Citation

Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor.

Avery, N.G, Yoshiyama, C.N, Taylor, A.L, Park, Y.J, Asarnow, D, Perruzza, L, Brown, J.T, Corti, D, Benigni, F, Starr, T.N, Veesler, D.Show

Proc.Natl.Acad.Sci.USA 123 e2533456123 e2533456123 (2026)

PMID: 42054371 DOI: 10.1073/pnas.2533456123

Primary Citation of related structures

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