11TU image
Deposition Date 2026-03-12
Release Date 2026-04-08
Last Version Date 2026-07-29
Entry Detail
PDB ID:
11TU
Keywords:
HYDROLASE
Title:
Crystal structure of alpha/beta-hydrolase macrolide esterase EstT from Bacillus cereus (S102A mutant) in complex with linearized tylvalosin
Biological Source:
Source Organism(s):
Bacillus cereus (Taxon ID: 1396)
Expression System(s):
Escherichia coli bl21
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.70 Å
R-Value Free:
0.20
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 41 21 2
11TU validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:alpha/beta-hydrolase macrolid
Gene (Uniprot):CN307_07515
Mutagens:S102A
Chain IDs:A
Chain Length:284
Number of Molecules:1
Biological Source:Bacillus cereus
UniProt ID:A0A2A9A3A8
Ligand Molecules
A1DAR
Primary Citation
Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.
Proc.Natl.Acad.Sci.USA 123 e2611077123 e2611077123 (2026)
PMID: 42455676 DOI: 10.1073/pnas.2611077123
Primary Citation of related structures
11TU
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