11SY image
Deposition Date 2026-03-11
Release Date 2026-04-22
Last Version Date 2026-04-22
Entry Detail
PDB ID:
11SY
Keywords:
HYDROLASE
Title:
Cryo-EM structure of substrate engaged p97-Ufd1-NPL4-Faf1 complex (NPL4 focused)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli 'bl21-gold(de3)plyss ag', Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.28 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
11SY validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nuclear protein localization
Gene (Uniprot):NPLOC4
Chain IDs:A (auth: G)
Chain Length:611
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q8TAT6 Pfam ID:PF11543, PF05020, PF05021
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin
Gene (Uniprot):UBC
Chain IDs:B (auth: H), C (auth: I), D (auth: J), E (auth: K)
Chain Length:76
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P0CG48 Pfam ID:PF00240
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ubiquitin recognition factor
Gene (Uniprot):UFD1
Chain IDs:F (auth: P)
Chain Length:313
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q92890 Pfam ID:PF03152, PF24842
Ligand Molecules
ZN
Primary Citation
Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagement
To Be Published ? ? ? (?)
Primary Citation of related structures
9YW2
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