11SS image
Deposition Date 2026-03-11
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
11SS
Title:
Cryo-EM structure of DNA polymerase Zeta with RNA:DNA hybrid and incoming dNTP
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
3.03 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:DNA polymerase zeta catalytic
Gene (Uniprot):REV3
Chain IDs:A
Chain Length:1538
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
Polymer Type:polypeptide(L)
Molecule:DNA repair protein REV1
Gene (Uniprot):REV1
Chain IDs:E (auth: B)
Chain Length:985
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
Polymer Type:polypeptide(L)
Molecule:DNA polymerase zeta processiv
Gene (Uniprot):REV7
Chain IDs:B (auth: D), C (auth: E)
Chain Length:245
Number of Molecules:2
Biological Source:Saccharomyces cerevisiae
Polymer Type:polypeptide(L)
Molecule:DNA polymerase delta small su
Gene (Uniprot):POL31
Chain IDs:G (auth: F)
Chain Length:494
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
Polymer Type:polypeptide(L)
Molecule:DNA polymerase delta subunit
Gene (Uniprot):POL32
Chain IDs:D (auth: G)
Chain Length:350
Number of Molecules:1
Biological Source:Saccharomyces cerevisiae
Polymer Type:polydeoxyribonucleotide
Molecule:DNA (5'-D(P*AP*TP*TP*AP*CP*GP
Chain IDs:F (auth: P)
Chain Length:20
Number of Molecules:1
Biological Source:synthetic construct
Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*AP*AP*UP*GP*GP*CP
Chain IDs:H (auth: X)
Chain Length:25
Number of Molecules:1
Biological Source:synthetic construct
Primary Citation
Molecular basis of DNA polymerase zeta's reverse transcriptase activity
Nat Commun ? ? ? (2026)
DOI: 10.1038/s41467-026-78032-8
Primary Citation of related structures
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