ISDA: 11RM

Deposition Date 2026-03-10

Release Date 2026-07-29

Last Version Date 2026-07-29

Entry Detail

PDB ID:

11RM

Keywords:

PROTEIN TRANSPORT

Title:

Cryo-EM structure of human exportin-1 conjugated with FR-027*

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.95 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Exportin-1
Gene (Uniprot):XPO1
Chain IDs:A
Chain Length:1073
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:O14980 Pfam ID:PF03810, PF08389, PF18777, PF18784, PF18787, PF08767

Ligand Molecules

A1DBJ

Primary Citation

Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy

Van Hauwenhuyse, J, Reniers, F, Persoons, L, Noppen, S, Wing, C.E, Niesman, A.B, Fung, H.Y.J, Vanstreels, E, Jacquemyn, M, Boel, E, Vankerckhoven, A, Berckmans, Y, Kwanten, B, Coosemans, A, Van den Mooter, G, Chook, Y.M, Dehaen, W, Daelemans, D.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-75741-y

Primary Citation of related structures

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