ISDA: 11MQ

Deposition Date 2026-03-05

Release Date 2026-07-22

Last Version Date 2026-07-22

Entry Detail

PDB ID:

11MQ

Keywords:

DE NOVO PROTEIN

Title:

Crystal Structure of Fluorophore-binding Protein NovoTag657-holo

Biological Source:

Source Organism(s):

synthetic construct (Taxon ID: 32630)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.38 Å

R-Value Free:

0.28

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:NovoTag657-holo
Chain IDs:A
Chain Length:135
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

A1DMM

SO4

Primary Citation

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Tran, L, Klein, S, Juergens, D, Sharma, S, Decarreau, J, Lee, G.R, Wang, Y, Chen, W, Bera, A.K, Kang, A, Woods, J, Joyce, E, Vafeados, D.K, Roullier, N, Li, X, Liu, B, Bo, Y, Muratspahic, E, Brown, T.A, Grimm, J.B, Patel, R, Lavis, L.D, Mahamid, J, An, L, Baker, D.Show

Science ? ? ? (2026)

DOI: 10.1126/science.aeb0822

Primary Citation of related structures

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