ISDA: 11LQ

Deposition Date 2026-03-03

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

11LQ

Keywords:

VIRAL PROTEIN

Title:

Human monoclonal antibodies 4C12 and 4H3 in complex with rabies virus glycoprotein

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Lyssavirus rabies (Taxon ID: 11292)

Expression System(s):

Drosophila melanogaster, Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.24 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Glycoprotein
Chain IDs:E (auth: A), L (auth: B), M (auth: C)
Chain Length:468
Number of Molecules:3
Biological Source:Lyssavirus rabies

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody RVA122 Li
Chain IDs:A (auth: D), C (auth: F), F (auth: H)
Chain Length:217
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody RVA122 He
Chain IDs:B (auth: E), D (auth: G), G (auth: I)
Chain Length:265
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody 4H3 Light
Chain IDs:H (auth: J), J (auth: L), K (auth: N)
Chain Length:216
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody 4H3 Heavy
Chain IDs:P (auth: K), Q (auth: M), R (auth: O)
Chain Length:266
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody 4C12 Heav
Chain IDs:S (auth: R), T, U (auth: V)
Chain Length:270
Number of Molecules:3
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:Monoclonal Antibody 4C12 Ligh
Chain IDs:I (auth: S), N (auth: U), O (auth: Q)
Chain Length:216
Number of Molecules:3
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Antigenic landscape of rabies and related lyssaviruses revealed by cryo-EM

Callaway, H.M, Zyla, D, Hastie, K, Harkins, S, Kothalawalage, S, Samarasinghe, S, Flynn, A, Hariharan, C, Yin, J, Corti, D, Bouhry, H, Dessain, S, Saphire, E.O.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form