ISDA: 11HQ

Deposition Date 2026-02-25

Release Date 2026-05-27

Last Version Date 2026-07-01

Entry Detail

PDB ID:

11HQ

Keywords:

TRANSFERASE

Title:

Type-III c-MET Inhibitor Enabled by Free-Energy Perturbation Calculations

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.65 Å

R-Value Free:

0.28

R-Value Work:

0.22

Space Group:

P 21 2 21

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Hepatocyte growth factor rece
Gene (Uniprot):MET
Mutagens:L1272V
Chain IDs:A, B, C
Chain Length:310
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P08581 Pfam ID:PF07714 EC:2.7.10.1

Ligand Molecules

A1C9B

Primary Citation

Discovery of 2H-Pyrrolo[3,4‐ c ]pyridin-3-one Derivatives as Type-III c‐MET Inhibitors Enabled by Free-Energy Perturbation Calculations.

Therrien, E, Feng, S, Amberg-Johnson, K, Shaikh, N, Patil, P, Majumdar, S, Abraham, N, Eiler, D, Kutter, S, Albanese, S.K, Haldar, S, Kroeck, K.G, Atsriku, C, Gerasyuto, A.I, Levinson, A.M.Show

Acs Med.Chem.Lett. 17 1364 1372 (2026)

PMID: 42305208 DOI: 10.1021/acsmedchemlett.6c00158

Abstact

The clinical emergence of diverse c-MET mutations with resistance to approved inhibitors has created an urgent demand for next-generation inhibitors with efficacy against c-MET-resistant mutations while maintaining c-MET wild-type (WT) potency, selectivity over other kinases, and brain penetration. Here, we report a novel chemical series discovered through iterative core enumeration and decoration guided by free energy perturbation calculations. Type-III inhibitor 20 demonstrated potent activity against both WT and c-MET with the D1228V resistance mutation with promising physicochemical properties, laying the foundation for the development of brain-penetrant therapies targeting c-MET-driven cancers.

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Primary Citation of related structures

Abstact

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