ISDA: 11HC

Deposition Date 2026-02-23

Release Date 2026-08-26

Last Version Date 2026-08-26

Entry Detail

PDB ID:

11HC

Keywords:

RNA BINDING PROTEIN

Title:

Effector complex from type IV-C CRISPR-Cas system

Biological Source:

Source Organism(s):

Pyrococcus abyssi (Taxon ID: 29292)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.37 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Cas10IVc
Chain IDs:A
Chain Length:608
Number of Molecules:1
Biological Source:Pyrococcus abyssi

Polymer Type:polypeptide(L)
Molecule:Cas5c
Chain IDs:B
Chain Length:306
Number of Molecules:1
Biological Source:Pyrococcus abyssi

Polymer Type:polypeptide(L)
Molecule:Cas7c
Chain IDs:C, D, E, F, G, H, I
Chain Length:330
Number of Molecules:7
Biological Source:Pyrococcus abyssi

Polymer Type:polypeptide(L)
Molecule:Cas11c
Chain IDs:J (auth: K), K (auth: L), L (auth: M), M (auth: N), N (auth: O), O (auth: P)
Chain Length:124
Number of Molecules:6
Biological Source:Pyrococcus abyssi

Polymer Type:polyribonucleotide
Molecule:crRNA (47-MER)
Chain IDs:P (auth: R)
Chain Length:47
Number of Molecules:1
Biological Source:Pyrococcus abyssi

Polymer Type:polydeoxyribonucleotide
Molecule:DNA (30-MER)
Chain IDs:Q (auth: S)
Chain Length:30
Number of Molecules:1
Biological Source:Pyrococcus abyssi

Ligand Molecules

Primary Citation

Type IV-C CRISPR-Cas effector complex recognizes double-stranded DNA and switches on collateral cleavage of ssDNA and RNA

Pittman, C, Xu, C, Catchpole, R, Garrett, S, Fuchs, R, Makarova, K, Koonin, E, Zhao, P, Wells, L, Graveley, B, Chu, X, Ke, A, Terns, M.Show

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Primary Citation of related structures

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