11GV image
Deposition Date 2026-02-23
Release Date 2026-09-02
Last Version Date 2026-09-02
Entry Detail
PDB ID:
11GV
Keywords:
SIGNALING PROTEIN
Title:
Crystal structure of selective inhibitor 16 bound at the active site of CDK2
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.59 Å
R-Value Free:
0.19
R-Value Work:
0.16
R-Value Observed:
0.17
Space Group:
C 2 2 21
11GV validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Cyclin-dependent kinase 2
Chain IDs:A
Chain Length:298
Number of Molecules:1
Biological Source:Homo sapiens
Polymer Type:polypeptide(L)
Molecule:Cyclin-A2
Chain IDs:B
Chain Length:260
Number of Molecules:1
Biological Source:Homo sapiens
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
TPO A THR modified residue
Ligand Molecules
A1DEQ
CL
DMS
EDO
IPA
MG
Primary Citation
Utilizing Molecular Dynamics and Mechanistic Pharmacokinetic Studies in the Design of Selective CDK2 Inhibitors.
J.Med.Chem. 69 15294 15316 (2026)
PMID: 42328801 DOI: 10.1021/acs.jmedchem.5c03803
Primary Citation of related structures
11GV
Feedback Form
Name
Email
Institute
Feedback