11GH image
Deposition Date 2026-02-22
Release Date 2026-10-07
Last Version Date 2026-10-07
Entry Detail
PDB ID:
11GH
Keywords:
SIGNALING PROTEIN
Title:
Structure of GMPPNP-bound KRAS-G12C/Y96D, a Switch-II Pocket Inhibitor Resistance Mutant, in Complex with the RAF1 RBD-CRD
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.50 Å
R-Value Free:
0.25
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 6 2 2
11GH validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12C,Y96D,C118S
Chain IDs:A
Chain Length:170
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:RAF proto-oncogene serine/thr
Gene (Uniprot):RAF1
Chain IDs:B
Chain Length:138
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P04049 Pfam ID:PF02196, PF00130 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CAF B CYS modified residue
Ligand Molecules
GNP
MG
ZN
Primary Citation
Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS
Nat Commun ? ? ? (2026)
DOI: 10.1038/s41467-026-78133-4
Primary Citation of related structures
11GH
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