ISDA: 11ES

Deposition Date 2026-02-19

Release Date 2026-10-07

Last Version Date 2026-10-07

Entry Detail

PDB ID:

11ES

Keywords:

SIGNALING PROTEIN

Title:

Structure of GDP-bound KRAS-G12C/H95Q, a Switch-II Pocket Inhibitor Resistance Mutant

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.35 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

H 3 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Isoform 2B of GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12C, H95Q, C118S
Chain IDs:A
Chain Length:170
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

GDP

Primary Citation

Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRAS

Whitley, M.J, Dyba, M, Chakrabarti, M, Smith, B.P, Chan, A.H, Denson, J.P, Messing, S.A, Lin, K, Cornilescu, G, Balius, T.E, Nissley, D.V, McCormick, F, Maciag, A.E, Simanshu, D.K.Show

Nat Commun ? ? ? (2026)

DOI: 10.1038/s41467-026-78133-4

Primary Citation of related structures

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