ISDA: 10WP

Deposition Date 2026-02-11

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

10WP

Keywords:

VIRUS

Title:

MPXV replisome bound to forked DNA

Biological Source:

Source Organism(s):

Monkeypox virus (Taxon ID: 10244)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

6.50 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:DNA polymerase
Chain IDs:G (auth: A)
Chain Length:1006
Number of Molecules:1
Biological Source:Monkeypox virus

Polymer Type:polypeptide(L)
Molecule:Uracil-DNA glycosylase
Chain IDs:I (auth: B)
Chain Length:218
Number of Molecules:1
Biological Source:Monkeypox virus

Polymer Type:polypeptide(L)
Molecule:DNA polymerase processivity f
Chain IDs:H (auth: C)
Chain Length:426
Number of Molecules:1
Biological Source:Monkeypox virus

Polymer Type:polypeptide(L)
Molecule:Uncoating factor OPG117
Chain IDs:A (auth: D), B (auth: E), C (auth: I), D (auth: F), E (auth: H), J (auth: G)
Chain Length:785
Number of Molecules:6
Biological Source:Monkeypox virus

Polymer Type:polydeoxyribonucleotide
Molecule:leading strand
Chain IDs:K (auth: S)
Chain Length:22
Number of Molecules:1
Biological Source:Monkeypox virus

Polymer Type:polydeoxyribonucleotide
Molecule:lagging strand
Chain IDs:F (auth: T)
Chain Length:27
Number of Molecules:1
Biological Source:Monkeypox virus

Ligand Molecules

Primary Citation

Structure and operating principles of a monkeypox virus replisome

Yu, Z, Sathyanarayana, P, Tan, J.M.J.T, Hu, S, Fan, X, Gao, A, Kranzusch, P.J, Loparo, J.J, Abraham, J.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-10937-2

Primary Citation of related structures

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