ISDA: 10VC

Deposition Date 2026-02-10

Release Date 2026-04-29

Last Version Date 2026-04-29

Entry Detail

PDB ID:

10VC

Keywords:

DNA BINDING PROTEIN

Title:

Crystal structure of GeoCas9 HNH domain bound to anti-CRISPR AcrIIC1

Biological Source:

Source Organism(s):

Geobacillus stearothermophilus (Taxon ID: 1422)
Neisseria meningitidis (Taxon ID: 487)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:CRISPR-associated endonucleas
Chain IDs:A, C, E, G, I, K
Chain Length:111
Number of Molecules:6
Biological Source:Geobacillus stearothermophilus

UniProt ID:A0ABF7PG96

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Anti-CRISPR protein (AcrIIC1)
Chain IDs:B, D, F, H, J, L
Chain Length:86
Number of Molecules:6
Biological Source:Neisseria meningitidis

UniProt ID:A0A2D0TCG3

Primary Citation

Orthosteric and allosteric effects of anti-CRISPR II-C1 inhibition on Geo Cas9 from integrated structural biophysics.

Knight, A.L, Belato, H.B, Dresser, C.S, Pindi, C, Mercado, B.J, Lasekan, P, Luo, J, Arantes, P.R, Jogl, G, Palermo, G, Lisi, G.P.Show

Biorxiv ? ? ? (2026)

PMID: 41993526 DOI: 10.64898/2026.04.08.717222

Primary Citation of related structures

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