ISDA: 10TX

Deposition Date 2026-02-09

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

10TX

Keywords:

HYDROLASE

Title:

Tissue Non-specific Alkaline Phosphatase -S110A bound to PPi

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.25 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alkaline phosphatase, tissue-
Gene (Uniprot):Alpl
Mutagens:S110A
Chain IDs:A, B, C, D
Chain Length:493
Number of Molecules:4
Biological Source:Mus musculus

UniProt ID:P09242 EC:3.1.3.1

Ligand Molecules

FLC

GOL

NAG

PO4

POP

Primary Citation

Glycerol-driven TNAP activation in thermogenesis and mineralization

Hussain, M.F, Krishnan, S.S, Carroll, B.L, Bozena, S, Mousa, A, Williamson, A, Srinivasu, B.Y, Bunk, J, Delgado-Martin, M, Rahbani, J.F, Oppong, A, Roesler, A, Kaiser, Z, Ersin, M, Zhang, Q, Shaw, A, Cheng, J, Klemets, H, Kocsis Illes, K, DeMambro, V, Rosen, C.J, Millan, J.L, Wales, T.E, Langenberg, C, McKee, M.D, Guarne, A, Kazak, L.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-10396-9

Primary Citation of related structures

Feedback Form