ISDA: 10RY

Deposition Date 2026-02-04

Release Date 2026-08-19

Last Version Date 2026-08-19

Entry Detail

PDB ID:

10RY

Keywords:

HYDROLASE

Title:

Crystal structure of compound 8t bound to PaLpxC

Biological Source:

Source Organism(s):

Pseudomonas aeruginosa (Taxon ID: 287)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.90 Å

R-Value Free:

0.22

R-Value Work:

0.19

Space Group:

P 63

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Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:UDP-3-O-acyl-N-acetylglucosam
Chain IDs:A
Chain Length:302
Number of Molecules:1
Biological Source:Pseudomonas aeruginosa

Ligand Molecules

A1C8O

SO4

Primary Citation

Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections

Martin, D.P, Teng, M, Nammalwar, B, Perez, C, Li, X, Munguia, J, Taganov, K, Fan, J, Agarwalla, S, Lonergan, D, Tomaras, A.P, Zimmerman, Z, Puerta, D.T.Show

J.Med.Chem. 69 18692 18704 (2026)

DOI: 10.1021/acs.jmedchem.6c01036

Primary Citation of related structures

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