ISDA: 10OT

Deposition Date 2026-01-29

Release Date 2026-10-07

Last Version Date 2026-10-07

Entry Detail

PDB ID:

10OT

Keywords:

HYDROLASE

Title:

Crystal structure of mouse CD38 in complex with compound 6

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)

Expression System(s):

Cricetulus griseus

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.15 Å

R-Value Free:

0.27

R-Value Work:

0.26

R-Value Observed:

0.26

Space Group:

P 21 2 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:ADP-ribosyl cyclase/cyclic AD
Gene (Uniprot):Cd38
Chain IDs:A, B
Chain Length:263
Number of Molecules:2
Biological Source:Mus musculus

UniProt ID:P56528 Pfam ID:PF02267 EC:2.4.99.20

Ligand Molecules

A1C64

ACT

Primary Citation

Design and Exploration of a Tricyclic Series of CNS-Penetrant CD38 Small Molecule Inhibitors

Hodges, T.R, Jang, Y, Korch, K, Osuma, A, Randolph, J.T, Shiroodi, R, Bergstrom, B.D, Brosey, C, Jejurkar, P, Sheehan, M.M, Sadowski, R.N, Lin, K.A, Brown, J.W, Balakrishnan, A, Zoi, I, Bigelow, L, Jain, R, Bradley, N.P, Chapman, A, Korepanova, A, Swensen, A.M, Benekareddy, M, Shotwell, J.B.Show

Acs Med.Chem.Lett. ? ? ? (2026)

DOI: 10.1021/acsmedchemlett.6c00301

Primary Citation of related structures

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