ISDA: 10OI

Deposition Date 2026-01-29

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

10OI

Keywords:

TRANSFERASE

Title:

Structure of Clostridium difficile Toxin B (TcdB) glucosyltransferase in complex with UDP linked isofagomine analog 3-5

Biological Source:

Source Organism(s):

Clostridioides difficile (Taxon ID: 1496)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.65 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Toxin B
Gene (Uniprot):tcdB
Chain IDs:A, B
Chain Length:552
Number of Molecules:2
Biological Source:Clostridioides difficile

UniProt ID:P18177 EC:2.4.1.B62

Ligand Molecules

A1C96

GOL

UDP

Primary Citation

Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.

Shaffer, K.J, Gilaj, N, Wagner, A.G, Popadynec, M, Groom, D.P, Hughes, L.A, Ghosh, A, Paparella, A, Tyler, P.C, Lamiable-Oulaidi, F, Schramm, V.L.Show

J.Med.Chem. ? ? ? (2026)

PMID: 42383693 DOI: 10.1021/acs.jmedchem.6c00369

Primary Citation of related structures

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