ISDA: 10NV

Deposition Date 2026-01-29

Release Date 2026-04-15

Last Version Date 2026-04-15

Entry Detail

PDB ID:

10NV

Keywords:

ONCOPROTEIN

Title:

Structure of kRas G12C Bound to Inhibitor 13ba

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.52 Å

R-Value Free:

0.20

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

P 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:GTPase KRas
Gene (Uniprot):KRAS
Mutagens:G12C; C51S; C80L; C118S
Chain IDs:A, B
Chain Length:170
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01116 Pfam ID:PF00071 EC:3.6.5.2

Ligand Molecules

A1C60

GDP

Primary Citation

Optimization of Covalent 6-Cyanoquinazoline KRAS G12C Inhibitors for the Treatment of Solid Tumors.

Waldo, J.P, Krawczuk, P.J, Kelly, C.B, Callas, C.G, Cisar, J.S, Eccles, W, Guerrero, C.A, Hack, M.D, Jones, W.M, Keohane, C.E, Li, L.S, Meegalla, S, Padilla-Salinas, R, Rosano, R.J, Shimkin, K.W, Simonnet, Y.R.F, Sitkoff, D, Sookezian, A, Winters, M.P, Bush, T.L, Cheung, S.T, Del Rosario, A.M, Hansen, R, Janes, M.R, Janjua, H, Kazmi, F, Kirkpatrick, R, La, D, Lenhart, R, Lorenzi, M.V, Liu, Y, Mesens, N, Milligan, C.M, Murrey, H, Peters, U, Ren, P, Richter, M, Rizzolio, M, Rao, S, Shaffer, P, Stratton, C.F, Szewczuk, L.M, Wen, J, Wong, V, Yanovich, C, Laquerre, S, Edwards, J.P, Leonard, K.A.Show

J.Med.Chem. ? ? ? (2026)

PMID: 41921095 DOI: 10.1021/acs.jmedchem.5c03610

Primary Citation of related structures

Feedback Form