ISDA: 10NP

Deposition Date 2026-01-28

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

10NP

Keywords:

STRUCTURAL PROTEIN

Title:

u-VT Ib tau filament from VT Case 1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.51 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Microtubule-associated protei
Chain IDs:A (auth: C), B (auth: E), C (auth: A), D, E (auth: F), F (auth: B), G (auth: I), H (auth: K), I (auth: G), J, K (auth: L), L (auth: H), M (auth: O), N (auth: Q), O (auth: M), P, Q (auth: R), R (auth: N)
Chain Length:75
Number of Molecules:18
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Repositioning of polyubiquitin alters the pathologic tau filament structure

Watanabe, R, Creekmore, B.C, Darwich, N.F, Smith, C.L, Xu, H, Baltazar, A, Salphati, S, Changolkar, L, Hoxha, K, Zhang, B, O'Rourke, C.M, Burslem, G.M, Lee, V.M.-Y, Chang, Y.-W, Lee, E.B.Show

Nat.Struct.Mol.Biol. ? ? ? (2026)

DOI: 10.1038/s41594-026-01879-4

Primary Citation of related structures

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