ISDA: 10NK

Deposition Date 2026-01-28

Release Date 2026-09-02

Last Version Date 2026-09-02

Entry Detail

PDB ID:

10NK

Keywords:

TRANSPORT PROTEIN

Title:

Xenopus KCNQ1 Intermediate State (E1R/R2E) in complex with UCL2077

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Xenopus laevis (Taxon ID: 8355)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.95 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Potassium voltage-gated chann
Mutagens:E150R, R221E
Chain IDs:C (auth: A), D (auth: G), G (auth: F), H
Chain Length:545
Number of Molecules:4
Biological Source:Xenopus laevis

Polymer Type:polypeptide(L)
Molecule:Calmodulin-1
Chain IDs:A (auth: B), B (auth: D), E (auth: C), F (auth: E)
Chain Length:149
Number of Molecules:4
Biological Source:Homo sapiens

Ligand Molecules

A1C6W

Primary Citation

Structural and kinetic mechanisms of state-dependent potassium channel inhibition

Kyriakis, E, Roscioni, A, Eldstrom, J, Sastre, D, Dou, Y, Taddei, A, Molinarolo, S, Tian, M, Maragliano, L, Van Petegem, F, Fedida, D.Show

Sci Adv ? ? ? (2026)

Primary Citation of related structures

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