ISDA: 10NE

Deposition Date 2026-01-28

Release Date 2026-10-21

Last Version Date 2026-10-21

Entry Detail

PDB ID:

10NE

Keywords:

IMMUNE SYSTEM

Title:

Cryo-EM structure of human IL-10RA and IL-10RB in complex with tandem VHHs E07-A05

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.14 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Interleukin-10 receptor subun
Gene (Uniprot):IL10RA
Chain IDs:A
Chain Length:227
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q13651

Polymer Type:polypeptide(L)
Molecule:tandem VHHs E07-A05
Chain IDs:B
Chain Length:258
Number of Molecules:1
Biological Source:synthetic construct

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Interleukin-10 receptor subun
Gene (Uniprot):IL10RB
Chain IDs:C
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q08334

Polymer Type:polypeptide(L)
Molecule:Fab Heavy Chain
Chain IDs:D (auth: H)
Chain Length:239
Number of Molecules:1
Biological Source:synthetic construct

Polymer Type:polypeptide(L)
Molecule:Fab Light Chain
Chain IDs:E (auth: L)
Chain Length:215
Number of Molecules:1
Biological Source:synthetic construct

Ligand Molecules

NAG

Primary Citation

Cryo-EM structure of human IL-10RA and IL-10RB in complex with tandem VHHs E07-A05

Xu, H.Show

Nature ? ? ? (2026)

DOI: 10.1038/s41586-026-11176-1

Primary Citation of related structures

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