ISDA: 10KV

Deposition Date 2026-01-25

Release Date 2026-07-08

Last Version Date 2026-07-15

Entry Detail

PDB ID:

10KV

Keywords:

HYDROLASE

Title:

Structure of hNSP4 bound to MCP4 at 2.75 A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.75 Å

R-Value Free:

0.27

R-Value Work:

0.24

R-Value Observed:

0.25

Space Group:

P 41 21 2

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Serine protease 57
Chain IDs:A (auth: B)
Chain Length:250
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MCP4
Chain IDs:B (auth: E)
Chain Length:16
Number of Molecules:1
Biological Source:synthetic construct

Primary Citation

Novel Macrocyclic Peptides as Potent and Selective Inhibitors of Human Neutrophil Serine Protease 4.

Tang, W, Ultsch, M, Adaligil, E, Tombling, B, Fleming, S, Wei, Y, Martinez, O.E, Song, A, Di Lello, P, Sudhamsu, J, Cunningham, C.N, Kirchhofer, D.Show

J.Mol.Biol. 438 169894 169894 (2026)

PMID: 42264133 DOI: 10.1016/j.jmb.2026.169894

Primary Citation of related structures

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