ISDA: 10KU

Deposition Date 2026-01-25

Release Date 2026-07-08

Last Version Date 2026-07-08

Entry Detail

PDB ID:

10KU

Keywords:

HYDROLASE

Title:

Structure of hNSP4-S218A bound to MCP3 at 2.09 A resolution

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
synthetic construct (Taxon ID: 32630)

Expression System(s):

Trichoplusia ni

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.09 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Serine protease 57
Gene (Uniprot):PRSS57
Chain IDs:A, B, C, D
Chain Length:232
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q6UWY2 Pfam ID:PF00089 EC:3.4.21.-

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MCP3
Chain IDs:E (auth: G), F (auth: I), G (auth: F), H (auth: E)
Chain Length:15
Number of Molecules:4
Biological Source:synthetic construct

Ligand Molecules

SO4

Primary Citation

Novel macrocyclic peptides as potent and selective inhibitors of human neutrophil serine protease 4.

Tang, W, Ultsch, M, Adaligil, E, Tombling, B, Fleming, S, Wei, Y, Martinez, O.E, Song, A, Lello, P.D, Sudhamsu, J, Cunningham, C.N, Kirchhofer, D.Show

J.Mol.Biol. ? 169894 169894 (2026)

PMID: 42264133 DOI: 10.1016/j.jmb.2026.169894

Primary Citation of related structures

Feedback Form