ISDA: 10JG

Deposition Date 2026-01-22

Release Date 2026-09-23

Last Version Date 2026-09-23

Entry Detail

PDB ID:

10JG

Keywords:

HYDROLASE/RNA

Title:

Structure of Human Argonaute2-miR200b RISC bound to 13nt long target in open conformation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.60 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein argonaute-2
Gene (Uniprot):AGO2
Chain IDs:C (auth: A)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9UKV8 Pfam ID:PF16486, PF08699, PF02170, PF16488, PF16487, PF02171 EC:3.1.26.-

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*UP*AP*AP*UP*AP*CP
Chain IDs:A (auth: C)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polyribonucleotide
Molecule:RNA (5'-R(P*CP*CP*UP*AP*UP*CP
Chain IDs:B (auth: D)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Structure of Human Argonaute2-miR200b RISC bound to 13nt long target in open conformation

Garg, A, Joshua-Tor, L.Show

To Be Published ? ? ? (?)

Primary Citation of related structures

Feedback Form