10HM image
Deposition Date 2026-01-20
Release Date 2026-06-17
Last Version Date 2026-06-17
Entry Detail
PDB ID:
10HM
Keywords:
TRANSFERASE/Inhibitor
Title:
Trypanosoma brucei CLK1 kinase domain in complex with a covalent Amidobenzimidazole (AB4) inhibitor
Biological Source:
Source Organism(s):
Trypanosoma brucei brucei TREU927 (Taxon ID: 185431)
Expression System(s):
Bacterial expression vector pail2
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.40 Å
R-Value Free:
0.33
R-Value Work:
0.29
R-Value Observed:
0.29
Space Group:
P 31
10HM validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein kinase, putative
Gene (Uniprot):Tb11.01.4230
Chain IDs:A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Chain Length:370
Number of Molecules:16
Biological Source:Trypanosoma brucei brucei TREU927
UniProt ID:Q382U0 Pfam ID:PF00069 EC:2.7.1.-
Ligand Molecules
A1C5R
DMS
SO4
Primary Citation
Trypanosoma brucei CLK1 kinase domain in complex with a covalent Amidobenzimidazole (AB4) inhibitor
To Be Published ? ? ? (?)
Primary Citation of related structures
10HM
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