10GA image
Deposition Date 2026-01-18
Release Date 2026-07-15
Last Version Date 2026-07-15
Entry Detail
PDB ID:
10GA
Keywords:
TRANSFERASE
Title:
Crystal Structure of Human Fgr SH3-SH2-High Affinity Linker Mutant 3 (HAL3) Domains.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli bl21(de3)
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.60 Å
R-Value Free:
0.19
R-Value Work:
0.16
Space Group:
P 1 21 1
10GA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase Fgr
Gene (Uniprot):FGR
Mutagens:T252P, A256R
Chain IDs:A
Chain Length:177
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P09769 Pfam ID:PF00018, PF00017 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CME A CYS modified residue
Ligand Molecules
GOL
Primary Citation
Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment.
Cell Rep 45 117551 117551 (2026)
PMID: 42301812 DOI: 10.1016/j.celrep.2026.117551
Primary Citation of related structures
10GA
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