ISDA: 10FS

Deposition Date 2026-01-17

Release Date 2026-07-15

Last Version Date 2026-07-15

Entry Detail

PDB ID:

10FS

Keywords:

TRANSFERASE

Title:

Crystal Structure of Human Fgr SH3-SH2-High Affinity Linker Mutant 1 (HAL1) Domains.

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.30 Å

R-Value Free:

0.19

R-Value Work:

0.18

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase Fgr
Gene (Uniprot):FGR
Chain IDs:A
Chain Length:172
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P09769 Pfam ID:PF00018, PF00017 EC:2.7.10.2

Ligand Molecules

GOL

PEG

Primary Citation

Constraining regulatory domain dynamics of the Src kinase Fgr increases ATP-site inhibitor sensitivity and impairs bone marrow engraftment.

Gonzalez-Areizaga, G, Shu, S.T, Alvarado, J.J, Shi, H, Chen, L, Smithgall, T.E.Show

Cell Rep 45 117551 117551 (2026)

PMID: 42301812 DOI: 10.1016/j.celrep.2026.117551

Primary Citation of related structures

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