ISDA: 10AY

Deposition Date 2026-01-09

Release Date 2026-04-22

Last Version Date 2026-04-22

Entry Detail

PDB ID:

10AY

Keywords:

CYTOSOLIC PROTEIN

Title:

Cryo-EM structure of CRBN-DDB1 in complex with HBS1L and TNG961

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Trichoplusia ni, Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:HBS1-like protein
Gene (Uniprot):HBS1L
Chain IDs:A, D
Chain Length:208
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9Y450 Pfam ID:PF03144, PF03143

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein cereblon
Gene (Uniprot):CRBN
Chain IDs:B, E
Chain Length:404
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q96SW2 Pfam ID:PF02190, PF03226

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:DNA damage-binding protein 1
Gene (Uniprot):DDB1
Chain IDs:C, F
Chain Length:1140
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q16531 Pfam ID:PF10433, PF23726, PF03178

Ligand Molecules