ISDA: 10AP

Deposition Date 2026-01-08

Release Date 2026-05-13

Last Version Date 2026-05-13

Entry Detail

PDB ID:

10AP

Keywords:

HYDROLASE

Title:

Crystal Structure of Human WRN helicase with compound 26

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.58 Å

R-Value Free:

0.28

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bifunctional 3'-5' exonucleas
Gene (Uniprot):WRN
Chain IDs:A
Chain Length:447
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14191 Pfam ID:PF00270, PF00271, PF16124 EC:3.6.4.12

Ligand Molecules

A1C4O

ATP

EDO

Primary Citation

Design of Cyclic Vinyl Sulfones as WRN Covalent Inhibitors from Noncovalent Binders.

Caravella, J.A, Toms, A.V, Sitnikov, N, Bartels, F, Svensson, R, O'Hagan, S.J, Borthwick, J.A, Campos, S, Yin, Y, Zhao, X, Li, L, Liu, R, Talbot, E, Kong, H, Adolf Freund, R.R, Browning, B, Genung, N.E, Carreiro, S, Brennan, D, Graves, A.P, Loh, C, Tummino, P, Edmondson, S.D, Li, D.Show

J.Med.Chem. ? ? ? (2026)

PMID: 42054607 DOI: 10.1021/acs.jmedchem.6c00328

Primary Citation of related structures

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