Search Count: 44
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Factor Xia (Pichia Pastoris; C500S [C122S]) In Complex With The Inhibitor Milvexian (Bms-986177), Iupac Name:(6R,10S)-10-{4-[5-Chloro-2-(4-Chloro-1H-1,2,3-Triazol-1-Yl)Phenyl]-6- Oxopyrimidin-1(6H)-Yl}-1-(Difluoromethyl)-6-Methyl-1,4,7,8,9,10-Hexahydro-15,11- (Metheno)Pyrazolo[4,3-B][1,7]Diazacyclotetradecin-5(6H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:0.92 Å Release Date: 2021-09-15 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: NAG, YXG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-09-15
Ligands: NAG, YXG
 |
Factor Xia In Complex With The Inhibitor Methyl ((10R,14S)- 14-(4-(3-Chloro-2,6-Difluorophenyl)-6-Oxo-3,6-Dihydro- 1(2H)-Pyridinyl)-10-Methyl-9-Oxo-8,16- Diazatricyclo[13.3.1.0~2,7~]Nonadeca-1(19),2,4,6,15,17- Hexaen-5-Yl)Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2020-06-10 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: SWP, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-06-10
Ligands: SWP, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(2R,7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-2-(Trifluoromethyl)-2,3,4,5,6,7-Hexahydro-1H-8,11-Epimino-1,9-Benzodiazacyclotridecin-14-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2020-01-29 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QLS, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-29
Ligands: QLS, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl (2R,7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-14-[(Methoxycarbonyl)Amino]-2,3,4,5,6,7-Hexahydro-1H-8,11-Epimino-1,9-Benzodiazacyclotridecine-2-Carboxylate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2020-01-29 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QLM, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-29
Ligands: QLM, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Ethyl (2R,7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-14-[(Methoxycarbonyl)Amino]-1,2,3,4,5,6,7,9-Octahydro-11,8-(Azeno)-1,9-Benzodiazacyclotridecine-2-Carboxylate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.07 Å Release Date: 2020-01-29 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QLD, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-29
Ligands: QLD, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Ethyl (2R,7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-15-[(Methoxycarbonyl)Amino]-2,3,4,5,6,7-Hexahydro-1H-12,8-(Metheno)-1,9-Benzodiazacyclotetradecine-2-Carboxylate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2020-01-29 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QLJ, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-29
Ligands: QLJ, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(3R,7S)-7-{[5-Amino-1-(3-Chloro-2-Fluorophenyl)-1H-Pyrazole-4-Carbonyl]Amino}-3-Methyl-2-Oxo-2,3,4,5,6,7-Hexahydro-1H-12,8-(Metheno)-1,9-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.23 Å Release Date: 2019-12-25 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QEY, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: QEY, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(3R,7S)-7-{[1-(3-Chloro-2-Fluorophenyl)-5-Methyl-1H-Imidazole-4-Carbonyl]Amino}-3-Methyl-2-Oxo-2,3,4,5,6,7-Hexahydro-1H-12,8-(Metheno)-1,9-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.53 Å Release Date: 2019-12-25 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QEV, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: QEV, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3-Phenyl-Pyrrolidin-2-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.64 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BUV, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BUV, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor 4-[[(1~{S})-2-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BUY, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BUY, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-Chloranyl-2-Fluoranyl-6-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Phenyl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BVJ, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BVJ, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor 4-[[(1~{S})-2-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-5-[(3~{S})-3-Ethoxycarbonylpiperidin-1-Yl]Carbonyl-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BVM, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BVM, SO4, EDO
 |
P130Cas Complex With Paxillin Ld1
Organism: Mus musculus
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2017-09-06 Classification: CELL ADHESION |
Organism: Mus musculus
Method: X-RAY DIFFRACTION
Release Date: 2017-09-06
 |
Factor Xia In Complex With The Inhibitor Methyl [(7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-2-Oxo-1,2,3,4,5,6,7,9-Octahydro-11,8-(Azeno)-1,9-Benzodiazacyclotridecin-14-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2017-07-12 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 9EY, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-07-12
Ligands: 9EY, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(4S,8S)-8-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-4-Methyl-2-Oxo-1,3,4,5,6,7,8,10-Octahydro-2H-12,9-(Azeno)-1,10-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2017-07-12 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 9FD, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-07-12
Ligands: 9FD, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(4R,5E,8S)-8-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-4-Methyl-2-Oxo-1,3,4,7,8,10-Hexahydro-2H-12,9-(Azeno)-1,10-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens, Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2017-07-12 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 9FA, SO4, EDO |
Organism: Homo sapiens, Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-07-12
Ligands: 9FA, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(3R,7S)-7-({(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}Amino)-3-Ethyl-2-Oxo-1,2,3,4,5,6,7,9-Octahydro-11,8-(Azeno)-1,9-Benzodiazacyclotridecin-14-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2017-07-12 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 9F7, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-07-12
Ligands: 9F7, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(4R,5E,8S)-11-Chloro-8-[(2,6-Difluoro-4-Methylbenzene-1-Carbonyl)Amino]-4-Methyl-2-Oxo-1,3,4,7,8,10-Hexahydro-2H-12,9-(Azeno)-1,10-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2017-07-12 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 9F1, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-07-12
Ligands: 9F1, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor ((15S)-18-Chloro- 15-(((2E)-3-(5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl)-2- Propenoyl)Amino)-17,19-Diazatricyclo[14.2.1.0~2,7~]Nonadeca-1(18),2,4,6,16(19)-Pentaen-5-Yl)Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2017-03-01 Classification: hydrolase/hydrolase inhibitor Ligands: 7DL, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-01
Ligands: 7DL, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl ((12E,15S)-15-(((2E)-3-(5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl)-2-Propenoyl)Amino)-9-Oxo-8,17,19-Triazatricyclo[14.2.1.0~2,7~]Nonadeca-1(18),2,4,6,12,16(19)-Hexaen-5-Yl)Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2017-03-01 Classification: hydrolase/hydrolase inhibitor Ligands: 7DS, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-01
Ligands: 7DS, SO4, EDO