Search Count: 44
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Factor Xia (Pichia Pastoris; C500S [C122S]) In Complex With The Inhibitor Milvexian (Bms-986177), Iupac Name:(6R,10S)-10-{4-[5-Chloro-2-(4-Chloro-1H-1,2,3-Triazol-1-Yl)Phenyl]-6- Oxopyrimidin-1(6H)-Yl}-1-(Difluoromethyl)-6-Methyl-1,4,7,8,9,10-Hexahydro-15,11- (Metheno)Pyrazolo[4,3-B][1,7]Diazacyclotetradecin-5(6H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:0.92 Å Release Date: 2021-09-15 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: NAG, YXG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-09-15
Ligands: NAG, YXG
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Factor Xia In Complex With The Inhibitor Methyl ((10R,14S)- 14-(4-(3-Chloro-2,6-Difluorophenyl)-6-Oxo-3,6-Dihydro- 1(2H)-Pyridinyl)-10-Methyl-9-Oxo-8,16- Diazatricyclo[13.3.1.0~2,7~]Nonadeca-1(19),2,4,6,15,17- Hexaen-5-Yl)Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2020-06-10 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: SWP, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-06-10
Ligands: SWP, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor Methyl [(3R,7S)-7-{[5-Amino-1-(3-Chloro-2-Fluorophenyl)-1H-Pyrazole-4-Carbonyl]Amino}-3-Methyl-2-Oxo-2,3,4,5,6,7-Hexahydro-1H-12,8-(Metheno)-1,9-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.23 Å Release Date: 2019-12-25 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QEY, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: QEY, SO4, EDO
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Factor Xia In Complex With The Inhibitor Methyl [(3R,7S)-7-{[1-(3-Chloro-2-Fluorophenyl)-5-Methyl-1H-Imidazole-4-Carbonyl]Amino}-3-Methyl-2-Oxo-2,3,4,5,6,7-Hexahydro-1H-12,8-(Metheno)-1,9-Benzodiazacyclotetradecin-15-Yl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.53 Å Release Date: 2019-12-25 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: QEV, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: QEV, SO4, EDO
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Factor Xia In Complex With The Inhibitor 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3-Phenyl-Pyrrolidin-2-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.64 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BUV, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BUV, SO4, EDO
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Factor Xia In Complex With The Inhibitor 4-[[(1~{S})-2-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BUY, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BUY, SO4, EDO
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Factor Xia In Complex With The Inhibitor Methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-Chloranyl-2-Fluoranyl-6-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Phenyl]Carbamate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BVJ, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BVJ, SO4, EDO
 |
Factor Xia In Complex With The Inhibitor 4-[[(1~{S})-2-[(~{E})-3-[5-Chloranyl-2-(1,2,3,4-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl]-5-[(3~{S})-3-Ethoxycarbonylpiperidin-1-Yl]Carbonyl-3,4-Dihydro-1~{H}-Isoquinolin-1-Yl]Carbonylamino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2017-11-08 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: BVM, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-11-08
Ligands: BVM, SO4, EDO
 |
Factor Viia In Complex With The Inhibitor 3-{[(2R)-17-Ethyl-4-Methyl-3,12-Dioxo-7-[(Propan-2-Yl)Sulfonyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7,9,16,19-Hexaen-2-Yl]Amino}Benzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2017-05-10 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 82J, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-05-10
Ligands: 82J, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor (5R)-5-[(1-Aminoisoquinolin-6-Yl)Amino]-19-(Cyclopropylsulfonyl)-3-Methyl-13-Oxa-3,15-Diazatricyclo[14.3.1.1~6,10~]Henicosa-1(20),6(21),7,9,16,18-Hexaene-4,14-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2017-02-01 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 7KQ, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-02-01
Ligands: 7KQ, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor (11R)-11-[(1-Aminoisoquinolin-6-Yl)Amino]-16-(Cyclopropylsulfonyl)-13-Methyl-2,13-Diazatricyclo[13.3.1.1~6,10~]Icosa-1(19),6(20),7,9,15,17-Hexaene-3,12-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2017-02-01 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 7KR, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-02-01
Ligands: 7KR, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor (5R,11R)-11-[(1-Amino-4-Fluoroisoquinolin-6-Yl)Amino]-16-(Cyclopropylsulfonyl)-7-(2,2-Difluoroethoxy)-5,13-Dimethyl-2,13-Diazatricyclo[13.3.1.1~6,10~]Icosa-1(19),6(20),7,9,15,17-Hexaene-3,12-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2017-02-01 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 7KS, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-02-01
Ligands: 7KS, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor 1-[(2R,15R)-2-[(1-Amino-4-Fluoroisoquinolin-6-Yl)Amino]-4,15,20-Trimethyl-3,12-Dioxo-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6,8,10(21),16,19-Hexaen-7-Yl] Cyclobutane-1-Carboxylic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.82 Å Release Date: 2016-09-28 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 70D, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-09-28
Ligands: 70D, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor 1-[(2R,15R)-2-[(1-Amino-4-Fluoroisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-3,12-Dioxo-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7,9,16,19-Hexaen-7-Yl]Cyclohexane-1-Carboxylic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.79 Å Release Date: 2016-09-28 Classification: Hydrolase/Hydrolase inhibitor Ligands: 70C, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-09-28
Ligands: 70C, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor (2R,15R)-2-[(1-Aminoisoquinolin-6-Yl)Amino]-4,15,17-Trimethyl-7-[1-(1H-Tetrazol-5-Yl)Cyclopropyl]-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2016-09-28 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 70A, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-09-28
Ligands: 70A, CA, SO4, GOL
 |
Factor Viia In Complex With The Inhibitor (2R,15R)-2-[(1-Aminoisoquinolin-6-Yl)Amino]-8-Fluoro-7-Hydroxy-4,15,17-Trimethyl-13-Oxa-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2016-06-22 Classification: Hydrolase/Hydrolase inhibitor Ligands: 67O, CA, SO4, MES |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-06-22
Ligands: 67O, CA, SO4, MES
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Factor Xia In Complex With The Inhibitor 4-[(N-{(2E)-3-[5-Chloro-2-(1H-Tetrazol-1-Yl)Phenyl]Prop-2-Enoyl}-L-Phenylalanyl)Amino]Benzoic Acid
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.08 Å Release Date: 2015-12-09 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 5JM, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-09
Ligands: 5JM, SO4, EDO
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Factor Xia In Complex With The Inhibitor N-[(1S)-1-Benzyl-2-[2-[5-Chloro-2-(Tetrazol-1-Yl)Phenyl]Ethylamino]-2-Oxo-Ethyl]-4-Hydroxy-2-Oxo-1H-Quinoline-6-Carboxamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2015-12-09 Classification: Hydrolase/Hydrolase Inhibitor Ligands: 7P0, SO4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-09
Ligands: 7P0, SO4, EDO
 |
Factor Viia In Complex With The Inhibitor N-{3-[(2R)-1-{(2R)-2-[(1-Aminoisoquinolin-6-Yl)Amino]-2-Phenylacetyl}Pyrrolidin-2-Yl]-4-(Propan-2-Ylsulfonyl)Phenyl}Acetamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2015-07-22 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 4T0, CA, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-07-22
Ligands: 4T0, CA, SO4
 |
Factor Viia In Complex With The Inhibitor (2R)-2-[(1-Aminoisoquinolin-6-Yl)Amino]-4,11-Diazatricyclo[14.2.2.1~6,10~]Henicosa-1(18),6(21),7,9,16,19-Hexaene-3,12-Dione
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2015-07-22 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 4T1, CA, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-07-22
Ligands: 4T1, CA, SO4, GOL