Search Count: 15
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Crystal Structure Of Sos1 With Mrtx0902, A Potent And Selective Inhibitor Of The Sos1:Kras Protein-Protein Interaction
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NKF |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NKF
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Crystal Structure Of Sos1 With Phthalazine Inhibitor Bound (Compound 15)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.29 Å Release Date: 2022-07-27 Classification: SIGNALING PROTEIN/INHIBITOR Ligands: NL0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-07-27
Ligands: NL0
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Kras G12D (Gppcp) With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2022-03-16 Classification: HYDROLASE/INHIBITOR Ligands: 6IC, GCP, GDP, GOL, ACT, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-03-16
Ligands: 6IC, GCP, GDP, GOL, ACT, MG
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
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Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG
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Potent, Reversible Metap2 Inhibitors Via Fragment Based Drug Discovery
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2016-05-25 Classification: Hydrolase/Hydrolase Inhibitor Ligands: MN, DMS, EDO, 6KP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: MN, DMS, EDO, 6KP
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Potent, Reversible Metap2 Inhibitors Via Fbdd
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2016-05-25 Classification: Hydrolase/Hydrolase Inhibitor Ligands: MN, GOL, DMS, 6KO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: MN, GOL, DMS, 6KO
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Potent, Reversible Metap2 Inhibitors Via Fbdd
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.15 Å Release Date: 2016-05-25 Classification: Hydrolase4/Hydrolase Inhibitor Ligands: MN, SO4, 6KN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-05-25
Ligands: MN, SO4, 6KN
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Characterization Of The Chk1 Allosteric Inhibitor Binding Site
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.76 Å Release Date: 2009-10-06 Classification: TRANSFERASE Ligands: AGX |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-10-06
Ligands: AGX
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Characterization Of The Chk1 Allosteric Inhibitor Binding Site
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2009-10-06 Classification: TRANSFERASE Ligands: AGY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2009-10-06
Ligands: AGY
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Crystal Structure Of Abad/Hsd10 With A Bound Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2004-10-05 Classification: OXIDOREDUCTASE Ligands: TDT, NAD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2004-10-05
Ligands: TDT, NAD