Search Count: 19
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From Dna-Encoded Library Screening To Am-9747 - An Mta-Cooperative Prmt5 Inhibitor With Potent Oral In Vivo Efficacy
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.25 Å Release Date: 2025-03-26 Classification: TRANSFERASE/INHIBITOR Ligands: A1BQW, MTA, GOL, PEG, DMS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-03-26
Ligands: A1BQW, MTA, GOL, PEG, DMS
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Crystal Structure Of Human Kras G12C Covalently Bound To Del Triazine Compound 5
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2025-02-26 Classification: SIGNALING PROTEIN,ONCOPROTEIN/INHIBITOR Ligands: CA, GDP, A1BH6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-26
Ligands: CA, GDP, A1BH6
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Crystal Structure Of Human Kras G12C Covalently Bound To Nopinone-Derived Naphthol Compound 21
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.18 Å Release Date: 2025-02-26 Classification: SIGNALING PROTEIN,ONCOPROTEIN/INHIBITOR Ligands: MG, GDP, A1BH5, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-02-26
Ligands: MG, GDP, A1BH5, EDO
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Glycosylase Muty Variant R149Q In Complex With Dna Containing D(8-Oxo-G) Paired With A Product Analog (Thf) To 1.51 A Resolution
Organism: Geobacillus stearothermophilus, Synthetic construct
Method: X-RAY DIFFRACTION Resolution:1.51 Å Release Date: 2024-10-30 Classification: HYDROLASE/DNA Ligands: SF4, ACY, CA |
Organism: Geobacillus stearothermophilus, Synthetic construct
Method: X-RAY DIFFRACTION
Release Date: 2024-10-30
Ligands: SF4, ACY, CA
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Amg 193, A Clinical Stage Mta-Cooperative Prmt5 Inhibitor, Drives Anti-Tumor Activity Preclinically And In Patients With Mtap-Deleted Cancers
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.85 Å Release Date: 2024-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: GOL, DMS, A1ATH, MTA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-02
Ligands: GOL, DMS, A1ATH, MTA
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Human Mutyh Adenine Glycosylase Bound To Dna Containing A Transition State Analog (1N) Paired With D(8-Oxo-G)
Organism: Homo sapiens, Synthetic construct
Method: X-RAY DIFFRACTION Resolution:1.91 Å Release Date: 2024-05-29 Classification: HYDROLASE/DNA Ligands: SF4, SO4 |
Organism: Homo sapiens, Synthetic construct
Method: X-RAY DIFFRACTION
Release Date: 2024-05-29
Ligands: SF4, SO4
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Crystal Structure Of Human Kras G12C Covalently Bound To A Phthalazine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2019-12-25 Classification: SIGNALING PROTEIN/Inhibitor Ligands: MG, GDP, OJ1 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: MG, GDP, OJ1
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Crystal Structure Of Human Kras G12C Covalently Bound To A Quinazolinone Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2019-12-25 Classification: SIGNALING PROTEIN/Inhibitor Ligands: GDP, CA, OHY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-12-25
Ligands: GDP, CA, OHY
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Crystal Structure Of Human Pim-1 Kinase In Complex With A Quinazolinone-Pyrrolodihydropyrrolone Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2019-01-16 Classification: TRANSFERASE Ligands: JYG, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-01-16
Ligands: JYG, GOL
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Crystal Structure Of Human Pim-1 Kinase In Complex With A Quinazolinone-Pyrrolopyrrolone Inhibitor.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2016-06-22 Classification: transferase/transferase inhibitor Ligands: 6CD, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-06-22
Ligands: 6CD, GOL
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Gkrp Bound To Amg0556 And Sorbitol-6-Phosphate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.39 Å Release Date: 2014-07-30 Classification: CARBOHYDRATE BINDING PROTEIN/INHIBITOR Ligands: 2UW, S6P, IOD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-07-30
Ligands: 2UW, S6P, IOD, GOL, SO4
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Gkrp Bound To Amg-0471 And Sorbitol-6-Phosphate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.24 Å Release Date: 2014-07-30 Classification: CARBOHYDRATE BINDING PROTEIN/INHIBITOR Ligands: 2UX, S6P, IOD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-07-30
Ligands: 2UX, S6P, IOD, GOL, SO4
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Human Gkrp Bound To Amg-5112 And Sorbitol-6-Phosphate
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.82 Å Release Date: 2014-07-30 Classification: CARBOHYDRATE BINDING PROTEIN/INHIBITOR Ligands: 2UY, S6P, IOD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-07-30
Ligands: 2UY, S6P, IOD, GOL, SO4
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Human Gkrp Complexed To Amg-3969 And S6P
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.22 Å Release Date: 2014-05-07 Classification: Transferase Inhibitor Ligands: MG9, S6P, IOD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-07
Ligands: MG9, S6P, IOD, GOL, SO4
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Human Gkrp Bound To Amg-5980 And S6P
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2014-05-07 Classification: Transferase Inhibitor Ligands: MG0, S6P, IOD, GOL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-07
Ligands: MG0, S6P, IOD, GOL, SO4
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Crystal Structure Of Human Pi3K-Gamma In Complex With Amg511
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.60 Å Release Date: 2012-08-29 Classification: Transferase/Inhibitor Ligands: SO4, 14K |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-08-29
Ligands: SO4, 14K
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Crystal Structure Of Human Pi3K-Gamma In Complex With A Pyridyl-Triazine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.95 Å Release Date: 2012-05-16 Classification: Transferase/Inhibitor Ligands: SO4, 0KO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-05-16
Ligands: SO4, 0KO
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Crystal Structure Of Pi3K-Gamma In Complex With A Quinoline Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.55 Å Release Date: 2011-06-08 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SO4, 2NQ |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-06-08
Ligands: SO4, 2NQ
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Crystal Structure Of P38 Alpha In Complex With A Selective Pyridazine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2005-04-26 Classification: TRANSFERASE Ligands: SO4, 6NP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2005-04-26
Ligands: SO4, 6NP