Search Count: 14
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Design And Synthesis Of Brain Penetrant Selective Jnk Inhibitors With Improved Pharmacokinetic Properties For The Prevention Of Neurodegeneration
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2013-05-08 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 34I |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-05-08
Ligands: 34I
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Structure-Based Design Of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2013-03-06 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, 0ZA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-03-06
Ligands: ZN, 0ZA
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Design And Synthesis Of Thiophene Dihydroisoquinolins As Novel Bace-1 Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2013-03-06 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, 1B9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-03-06
Ligands: ZN, 1B9
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Structure-Based Design Of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2013-03-06 Classification: hydrolase/hydrolase inhibitor Ligands: 1BB, ZN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-03-06
Ligands: 1BB, ZN
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Structure-Based Design Of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.07 Å Release Date: 2013-03-06 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, 1BS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-03-06
Ligands: ZN, 1BS
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Structure-Based Design Of Novel Dihydroisoquinoline Bace-1 Inhibitors That Do Not Engage The Catalytic Aspartates.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.89 Å Release Date: 2013-03-06 Classification: transferase/transferase inhibitor Ligands: ZN, 1CH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-03-06
Ligands: ZN, 1CH
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Design And Synthesis Of Hydroxyethylamine (Hea) Bace-1 Inhibitors: Prime Side Chromane-Containing Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2012-03-28 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: C6A |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-03-28
Ligands: C6A
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Highly Selective C-Jun N-Terminal Kinase (Jnk) 2 And 3 Inhibitors With In Vitro Cns-Like Pharmacokinetic Properties
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-08-17 Classification: transherase/transferase inhibitor Ligands: 589 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-17
Ligands: 589
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Design And Synthesis Of Disubstituted Thiophene And Thiazole Based Inhibitors Of Jnk For The Treatment Of Neurodegenerative Diseases
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2011-05-04 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SYY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-05-04
Ligands: SYY
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Design And Synthesis Of A Novel, Orally Efficacious Tri-Substituted Thiophene Based Jnk Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.43 Å Release Date: 2011-03-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 932 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-03-02
Ligands: 932
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Bace-1 In Complex With Eln380842
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2010-11-24 Classification: HYDROLASE/HYDROLASE inhibitor Ligands: 842 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-11-24
Ligands: 842
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Bace-1 In Complex With Eln475957
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-09-22 Classification: HYDROLASE Ligands: 957 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-09-22
Ligands: 957
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Design And Synthesis Of Potent Bace-1 Inhibitors With Cellular Activity: Structure-Activity Relationship Of P1 Substituents
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2010-01-05 Classification: HYDROLASE Ligands: 1LI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-01-05
Ligands: 1LI
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Design And Synthesis Of Potent Bace-1 Inhibitors With Cellular Activity: Structure-Activity Relationship Of P1 Substituents
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2010-01-05 Classification: HYDROLASE Ligands: SO4, GOL, 2LI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-01-05
Ligands: SO4, GOL, 2LI