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Structure Of Chk1 10-Pt. Mutant Complex With Macrocyclic Lrrk2 Inhibitor Compound 1 ((11R)-8-Chloro-3,11-Dimethyl-2-(Oxan-4-Yl)-2,4,10,11,12,13-Hexahydro-9,5-(Azeno)Pyrazolo[3,4-B][1,4,6,10]Oxatriazacyclotridecine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2026-04-08 Classification: TRANSFERASE/INHIBITOR Ligands: A1C5F |
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Structure Of Chk1 10-Pt. Mutant Complex With Macrocyclic Lrrk2 Inhibitor Compound 7 ((10As,13As)-3-Cyclobutyl-1-Methyl-8-(Trifluoromethyl)-3,4,10A,11,13A,14-Hexahydro-10H,13H-9,5-(Azeno)Furo[3,4-K]Pyrazolo[4,3-B][1,4,6,10]Oxatriazacyclotridecine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.67 Å Release Date: 2026-04-08 Classification: TRANSFERASE/INHIBITOR Ligands: A1C5G |
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Structure Of Chk1 10-Pt. Mutant Complex With Macrocyclic Lrrk2 Inhibitor Compound 12 ((10As,13As)-3-Cyclopropyl-1-Methyl-8-(Trifluoromethyl)-3,4,10A,11,13A,14-Hexahydro-10H,13H-9,5-(Azeno)Furo[3,4-K]Pyrazolo[4,3-B][1,4,6,10]Oxatriazacyclotridecine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.74 Å Release Date: 2026-04-08 Classification: TRANSFERASE/INHIBITOR Ligands: A1C5H |
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 4).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.58 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YO4, YNZ |
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket (Compound 5).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.20 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YOR, YNZ, CL |
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Pi3Ka H1047R Co-Crystal Structure With Inhibitors In Two Cryptic Pockets (Compounds 4 And 5).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.35 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YO4, YOR, YNZ |
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 12).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.93 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: 1LT, YQB |
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Pi3Ka H1047R Co-Crystal Structure With Inhibitor In Cryptic Pocket Near H1047R (Compound 7).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.61 Å Release Date: 2024-03-20 Classification: SIGNALING PROTEIN Ligands: YQ2, 1LT |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.92 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: DMS, SO4, THA |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.79 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: EDO, SO4, YIF |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: SO4, 6LH |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.44 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: QBC |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: SO4 |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.73 Å Release Date: 2024-01-10 Classification: SIGNALING PROTEIN Ligands: WRN |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.76 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXH |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.88 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXL |
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Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXP |