Search Count: 45
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Crystal Structure Of Human Dihydrofolate Reductase As Complex With Pyridopyrimidine 22 (N~6~-Methyl-N~6~-[4-(Propan-2-Yl)Phenyl]Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.61 Å Release Date: 2015-06-10 Classification: oxidoreductase/oxidoreductase inhibitor Ligands: NDP, IXF, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-06-10
Ligands: NDP, IXF, SO4
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Human Dihydrofolate Reductase Ternary Complex With Nadph And Inhibitor 26 (N~6~-Methyl-N~6~-(3,4,5-Trifluorophenyl)Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2015-06-10 Classification: oxidoreductase/oxidoreductase inhibitor Ligands: NDP, IXE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-06-10
Ligands: NDP, IXE
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Pneumocystis Carinii Dihydrofolate Reductase Ternary Complex With Nadph And The Inhibitor 24, (N~6~-Methyl-N~6~-(Naphthalen-1-Yl)Pyrido[2,3-D]Pyrimidine-2,4,6-Triamine)
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:1.61 Å Release Date: 2015-06-10 Classification: oxidoreductase/oxidoreductase inhibitor Ligands: 33M, NDP |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2015-06-10
Ligands: 33M, NDP
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Hdhfr-Oag Binary Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.35 Å Release Date: 2014-01-29 Classification: OXIDOREDUCTASE Ligands: OAG, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-01-29
Ligands: OAG, SO4
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Pcdhfr K37S/F69N Double Mutant Tmp Nadph Ternary Complex
Organism: Pneumocystis jirovecii
Method: X-RAY DIFFRACTION Resolution:1.75 Å Release Date: 2013-05-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: TOP, NDP |
Organism: Pneumocystis jirovecii
Method: X-RAY DIFFRACTION
Release Date: 2013-05-29
Ligands: TOP, NDP
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Lt-Iib-B5 S74D Mutant
Organism: Escherichia coli
Method: X-RAY DIFFRACTION Resolution:1.75 Å Release Date: 2012-11-21 Classification: TOXIN Ligands: ACT |
Organism: Escherichia coli
Method: X-RAY DIFFRACTION
Release Date: 2012-11-21
Ligands: ACT
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Heat-Labile Enterotoxin Lt-Iib-B5(T13I) Mutant
Organism: Escherichia coli
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2012-11-21 Classification: TOXIN |
Organism: Escherichia coli
Method: X-RAY DIFFRACTION
Release Date: 2012-11-21
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Heat-Labile Enterotoxin Ilt-Iibb5 S74A Mutant
Organism: Escherichia coli
Method: X-RAY DIFFRACTION Resolution:1.40 Å Release Date: 2012-11-21 Classification: TOXIN Ligands: SO4 |
Organism: Escherichia coli
Method: X-RAY DIFFRACTION
Release Date: 2012-11-21
Ligands: SO4
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Structural Analysis Of Pneumocystis Carinii Dihydrofolate Reductase Complex With Nadph And 2,4-Diamino-5-Methyl-6-[2'-(4-Carboxy-1-Pentynyl)-5'-Methoxybenzyl]Pyrido[2,3-D]Pyrimidine
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2012-04-11 Classification: OXIDOREDUCTASE Ligands: NDP, D2R |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2012-04-11
Ligands: NDP, D2R
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Human Dihydrofolate Reductase Binary Complex With Pt684
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2011-10-05 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: SO4, 684 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-10-05
Ligands: SO4, 684
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Hdhfr Double Mutant Q35S/N64F Trimethoprim Binary Complex
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.92 Å Release Date: 2011-09-28 Classification: OXIDOREDUCTASE Ligands: TOP, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-09-28
Ligands: TOP, SO4
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Human Dihydrofolate Reductase Q35K/N64F Double Mutant Binary Complex With Trimethoprim
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.53 Å Release Date: 2011-09-28 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: TOP, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-09-28
Ligands: TOP, SO4
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Structural And Kinetic Data For Antifolate Interactions Against Pneumocystis Jirovecii, Pneumocystis Carinii And Human Dihydrofolate Reductase And Thier Active Site Mutants
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2011-08-03 Classification: OXIDOREDUCTASE/INHIBITOR Ligands: OAG, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-03
Ligands: OAG, SO4
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Structural, Computational And Kinetic Data For Antifolate Interactions Against Pneumocystis Jirovecii, Pneumocystis Carinii And Human Dihydrofolate Reductase And Their Active Site Mutants
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2011-01-05 Classification: OXIDOREDUCTASE Ligands: OAG, NDP, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-01-05
Ligands: OAG, NDP, SO4
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Five Potent 5-(Omega-Carboxy(Alkyloxy)Pyrido[2,3-D]Pyrimidine Derivatives
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: D2J, NDP |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: D2J, NDP
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Five Potent 5-(Omega-Carboxy(Alkyloxy)Pyrido[2,3-D]Pyrimidine Derivatives
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: NDP, D2K |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: NDP, D2K
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Five Potent 5-(Omega-Carboxy(Alkyloxy)Pyrido[2,3-D]Pyrimidine Derivatives
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: NDP, D2K, CL |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: NDP, D2K, CL
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Potent 5-(Omega-Carboxyl(Alkyloxy)Pyrido[2,-D]Pyrimidine Derivatives
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:1.45 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: D2N, NDP |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: D2N, NDP
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Five Potent 5-(Omega-Carboxy(Alkyloxy)Pyrido[2,3-D]Pyridine Derivativea
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: D2O, PO4, GOL |
Organism: Pneumocystis carinii
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: D2O, PO4, GOL
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Structural Analysis Of Pneumocystis Carinii And Human Dhfr Complexes With Nadph And A Series Of Five 5-(Omega-Carboxy(Alkyloxy(Pyrido[2,3-D]Pyrimidine Derivatives
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2010-12-29 Classification: OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Ligands: D2Q, NDP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-12-29
Ligands: D2Q, NDP