Search Count: 20
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Crystal Structure Of Menin In Complex With Inhibitor Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVE
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Crystal Structure Of Menin In Complex With Inhibitor Compound 26
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVF, K, EPE, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVF, K, EPE, SO4
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Crystal Structure Of Menin In Complex With Inhibitor Compound 20
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVG
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
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Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG
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8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3J9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3J9
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8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UW |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UW
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8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UX |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UX
 |
8-Tetrahydropyran-2-Yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (Bace1) Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-12-03 Classification: hydrolase/hydrolase inhibitor Ligands: NI, 3UY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-12-03
Ligands: NI, 3UY
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Human B-Raf Kinase Domain In Complex With An Imidazopyridine-Based Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.60 Å Release Date: 2013-10-02 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: DFS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2013-10-02
Ligands: DFS
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Crystal Structure Of B-Raf Kinase Domain In Complex With A Dihydropyrido[2,3-D]Pyrimidinone-Based Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.60 Å Release Date: 2012-05-09 Classification: Transferase/Transferase Inhibitor Ligands: T1Q |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-05-09
Ligands: T1Q
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Human B-Raf Kinase Domain In Complex With An Bromopyridine Benzamide Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.40 Å Release Date: 2011-10-05 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: TV4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-10-05
Ligands: TV4
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Human B-Raf Kinase Domain In Complex With A Methoxypyrazolopyridinyl Benzamide Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.30 Å Release Date: 2011-10-05 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: B0R |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-10-05
Ligands: B0R
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Human B-Raf Kinase In Complex With An Amide Linked Pyrazolopyridine Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.20 Å Release Date: 2011-08-17 Classification: Transferase/Transferase Inhibitor Ligands: BR2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-08-17
Ligands: BR2
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Non-Oxime Pyrazole Based Inhibitors Of B-Raf Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.60 Å Release Date: 2011-05-18 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: SM7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2011-05-18
Ligands: SM7
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Pyrazole-Based Inhibitors Of B-Raf Kinase
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.80 Å Release Date: 2008-08-19 Classification: TRANSFERASE Ligands: SM5 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-08-19
Ligands: SM5