Search Count: 15
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Crystal Structure Of Human Wd Repeat-Containing Protein 5 In Complex With 4-(3,5-Dimethoxybenzyl)-9-(4-Fluoro-2-Methylphenyl)-7-((2-Imino-3-Methyl-2,3-Dihydro-1H-Imidazol-1-Yl)Methyl)-3,4-Dihydrobenzo[F][1,4]Oxazepin-5(2H)-One (Compound 8)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2023-12-20 Classification: TRANSCRIPTION Ligands: VV3 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-12-20
Ligands: VV3
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Discovery Of Potent Orally Bioavailable Wd Repeat Domain 5 (Wdr5) Inhibitors Using A Pharmacophore-Based Optimization
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.81 Å Release Date: 2022-05-04 Classification: Transcription/Transcription Inhibitor Ligands: MBU |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-05-04
Ligands: MBU
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Wdr5 Bound To 2-(3,5-Dimethoxybenzyl)-7-((2-Methyl-1H-Imidazol-1-Yl)Methyl)-5-(1-Methyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Yl)-3,4-Dihydroisoquinolin-1(2H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2022-04-27 Classification: Transcription/Transcription Inhibitor Ligands: BEN, M4U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-04-27
Ligands: BEN, M4U
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Structure Of Tim-3 In Complex With 8-Chloro-2-Methyl-9-(3-Mehtylpyridin-4-Yl)-[1,2,4]Triazolo[1,5-C]Quinazolin-5(6H)-One (Compound 22)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.69 Å Release Date: 2021-10-13 Classification: IMMUNE SYSTEM Ligands: YQ7, CA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-10-13
Ligands: YQ7, CA
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Structure Of Tim-3 In Complex With N-(4-(8-Chloro-2-Mehtyl-5-Oxo-5,6-Dihydro-[1,2,4]Triazolo[1,5-C]Quinazolin-9-Yl)-3-Methylphenyl)Methanesulfonamdide (Compound 35)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.40 Å Release Date: 2021-10-13 Classification: IMMUNE SYSTEM Ligands: YQD, CA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-10-13
Ligands: YQD, CA
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Structure Of Tim-3 In Complex With N-(4-(8-Chloro-2-Methyl-5-Oxo-5,6-Dihydro-[1,2,4]Traizolo[1,5-C]Quinazolin-9-Yl)-3-Methylphenyl)-1H-Imidazole-2-Sulfonamide (Compound 38)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.79 Å Release Date: 2021-10-13 Classification: IMMUNE SYSTEM Ligands: YQG, CA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-10-13
Ligands: YQG, CA
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Discovery And Structure-Based Optimization Of Potent And Selective Wdr5 Inhibitors Containing A Dihydroisoquinolinone Bicyclic Core
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2020-01-01 Classification: TRANSCRIPTION Ligands: Q41 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-01
Ligands: Q41
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Wd Repeat-Containing Protein 5 Complexed With N-[(3,5-Dimethoxyphenyl)Methyl]-4'-Fluoro-5-{[(2E)-2-Imino-3-Methyl-2,3-Dihydro-1H-Imidazol-1-Yl]Methyl}-2'-Methyl[1,1'-Biphenyl]-3-Carboxamide (Compound 13)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.02 Å Release Date: 2020-01-01 Classification: GENE REGULATION/INHIBITOR Ligands: Q6S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-01-01
Ligands: Q6S
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Discovery Of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate In Vivo Activity In Mouse Xenograft Models Of Human Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2019-04-17 Classification: APOPTOSIS Ligands: KJP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-04-17
Ligands: KJP
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Pd-L1 Igv Domain Bound To Fragment
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.43 Å Release Date: 2019-02-20 Classification: immune system/inhibitor Ligands: 22L |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
Ligands: 22L
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Igv-V76T Bms Compound 105
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.79 Å Release Date: 2019-02-20 Classification: immune system/inhibitor Ligands: KSD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
Ligands: KSD
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Pd-L1 Igv Domain Complex With Macro-Cyclic Peptide
Organism: Homo sapiens, Synthetic construct
Method: X-RAY DIFFRACTION Resolution:1.92 Å Release Date: 2019-02-20 Classification: IMMUNE SYSTEM |
Organism: Homo sapiens, Synthetic construct
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
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Pd-L1 Igv Domain V76T With Fragment
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.33 Å Release Date: 2019-02-20 Classification: IMMUNE SYSTEM Ligands: KW7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
Ligands: KW7
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Pd-L1 Igv Domain V76T With Fragment
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.70 Å Release Date: 2019-02-20 Classification: IMMUNE SYSTEM Ligands: KWA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
Ligands: KWA
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Pd-L1 Igv Domain V76T With Fragment
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2019-02-20 Classification: IMMUNE SYSTEM Ligands: SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2019-02-20
Ligands: SO4