Search Count: 20
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Discovery Of Mk-8189, A Highly Potent And Selective Pde10A Inhibitor For The Treatment Of Schizophrenia
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.02 Å Release Date: 2023-02-08 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: ZN, MG, S9I |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-02-08
Ligands: ZN, MG, S9I
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Pde10 Complexed With6-Chloro-N-[(2,4-Dimethylthiazol-5-Yl)Methyl]-5-Methyl-2-[2-(2-Pyridyl)Ethoxy]Pyrimidin-4-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2015-12-02 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4PX, 4Y1 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-12-02
Ligands: ZN, MG, 4PX, 4Y1
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Pde10 Complexed With 6-Chloro-N-[(2,4-Dimethylthiazol-5-Yl)Methyl]-5-Methyl-2-[3-(2-Quinolyl)Propoxy]Pyrimidin-4-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.09 Å Release Date: 2015-10-07 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4PX, 4XU |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-10-07
Ligands: ZN, MG, 4PX, 4XU
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Pde10 Complexed With 4,6-Dichloro-2-Cyclopropyl-5-Methyl-Pyrimidine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2015-09-30 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4XS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-09-30
Ligands: ZN, MG, 4XS
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Pde10 Complexed With 6-Chloro-2-Cyclopropyl-5-Methyl-Pyrimidin-4-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2015-09-30 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4XV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-09-30
Ligands: ZN, MG, 4XV
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Pde10 Complexed With 6-Chloro-2-Cyclopropyl-5-Methyl-N-Propyl-Pyrimidin-4-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2015-09-30 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4XY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-09-30
Ligands: ZN, MG, 4XY
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Pde10 Complexed With 6-Chloro-2-Cyclopropyl-N-[(2,4-Dimethylthiazol-5-Yl)Methyl]-5-Methyl-Pyrimidin-4-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2015-09-30 Classification: hydrolase/hydrolase inhibitor Ligands: ZN, MG, 4Y2 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-09-30
Ligands: ZN, MG, 4Y2
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Bace1 In Complex With 4-(Cyclohexylamino)-1-(3-Fluorophenyl)-8-(3-Isopropoxybenzyl)-1,3,8-Triazaspiro[4.5]Dec-3-En-2-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2015-08-05 Classification: Hydrolase/hydrolase inhibitor Ligands: 4QA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-08-05
Ligands: 4QA
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Bace1 In Complex With 8-(3-((1-Aminopropan-2-Yl)Oxy)Benzyl)-4-(Cyclohexylamino)-1-(3-Fluorophenyl)-1,3,8-Triazaspiro[4.5]Dec-3-En-2-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2015-08-05 Classification: Hydrolase/Hydrolase inhibitor Ligands: 4QD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-08-05
Ligands: 4QD
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Bace1 In Complex With 8-Benzyl-4-(Cyclohexylamino)-1-(3-Fluorophenyl)-7-Methyl-1,3,8-Triazaspiro[4.5]Dec-3-En-2-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2015-08-05 Classification: Hydrolase/hydrolase inhibitor Ligands: 4QF |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2015-08-05
Ligands: 4QF
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Human Bace (Beta Secretase) In Complex With Cyclohexanecarboxylic Acid (2-(2-Am Ino-6-Phenoxy-4H-Quinazolin-3-Yl)-2 -Cyclohexyl-Ethyl)- Amide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2010-03-02 Classification: HYDROLASE Ligands: QUD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2010-03-02
Ligands: QUD
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Crystal Structure Of Human Beta Secretase Complexed With I21
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2008-04-29 Classification: HYDROLASE Ligands: I21 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-04-29
Ligands: I21
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Crystal Structure Of Human Beta Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2008-04-22 Classification: HYDROLASE Ligands: SO4, 35A |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2008-04-22
Ligands: SO4, 35A
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Hiv Reverse Transcriptase In Complex With Inhibitor 7E (Nnrti)
Organism: Hiv-1 m:b_hxb2r
Method: X-RAY DIFFRACTION Resolution:2.40 Å Release Date: 2008-01-01 Classification: TRANSFERASE Ligands: MRX |
Organism: Hiv-1 m:b_hxb2r
Method: X-RAY DIFFRACTION
Release Date: 2008-01-01
Ligands: MRX
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Crystal Structure Of Human Bace-1 Bound To Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2007-11-13 Classification: HYDROLASE Ligands: L00 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2007-11-13
Ligands: L00
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Crystal Structure Of Human Beta Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2007-08-14 Classification: HYDROLASE Ligands: QIN |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2007-08-14
Ligands: QIN
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Crystal Structure Of Human Beta Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2007-08-14 Classification: HYDROLASE Ligands: MY9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2007-08-14
Ligands: MY9
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Crystal Structure Of Human Beta Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2007-06-05 Classification: HYDROLASE Ligands: SO4, 712 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2007-06-05
Ligands: SO4, 712
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Crystal Structure Of Human Beta-Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2006-11-14 Classification: HYDROLASE Ligands: I02 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-11-14
Ligands: I02
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Crystal Structure Of Human Beta-Secretase Complexed With Inhibitor
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.20 Å Release Date: 2006-11-14 Classification: HYDROLASE Ligands: I03 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2006-11-14
Ligands: I03