Search Count: 30
 |
Optimisation Of Potent, Efficacious, Selective And Blood-Brain Barrier Penetrating Inhibitors Targeting Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.44 Å Release Date: 2024-11-06 Classification: SIGNALING PROTEIN Ligands: A1H7N, IOD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-11-06
Ligands: A1H7N, IOD
 |
Optimisation Of Potent, Efficacious, Selective And Blood-Brain Barrier Penetrating Inhibitors Targeting Egfr Exon20 Insertion Mutations
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:3.02 Å Release Date: 2024-10-16 Classification: SIGNALING PROTEIN Ligands: A1H7O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-10-16
Ligands: A1H7O
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 16 Bound To Egfr
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.51 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2I0 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2I0
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 12 Bound To Egfrinsnpg
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.52 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2I6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2I6
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 22 Bound To Egfrinsnpg [V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.11 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2EI, IOD |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2EI, IOD
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 33 Bound To Egfrinsnpg [V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.28 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 26X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 26X
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 18 Bound To Egfr[V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.13 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 2II |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 2II
 |
Discovery And Optimisation Of Potent, Efficacious And Selective Inhibitors Targeting Egfr Exon20 Insertion Mutations. Compound 33 Bound To Egfr[V948R]
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2024-06-05 Classification: SIGNALING PROTEIN Ligands: 26X, ATP, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-06-05
Ligands: 26X, ATP, MG
 |
Crystal Structure Of D1228V C-Met Bound By Compound 29
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.77 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: GOL, EDO, FMT, W49 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: GOL, EDO, FMT, W49
 |
Crystal Structure Of D1228V C-Met Bound By Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: W3R, CL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: W3R, CL
 |
Crystal Structure Of D1228V C-Met Bound By Compound 10
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: W3W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: W3W
 |
Crystal Structure Of D1228V C-Met Bound By Compound 16
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.21 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: IOD, W3N |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: IOD, W3N
 |
Crystal Structure Of Wild-Type C-Met Bound By Compound 2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: W40 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: W40
 |
Crystal Structure Of D1228V C-Met Bound By Compound 2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.63 Å Release Date: 2023-07-05 Classification: TRANSFERASE Ligands: W40 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-07-05
Ligands: W40
 |
Crystal Structure Of Wild-Type C-Met Bound By Compound 7.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.39 Å Release Date: 2022-08-31 Classification: TRANSFERASE Ligands: SO4, MDI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-08-31
Ligands: SO4, MDI
 |
Crystal Structure Of D1228V C-Met Bound By Compound 1.
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.01 Å Release Date: 2022-08-31 Classification: TRANSFERASE Ligands: GOL, MDI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-08-31
Ligands: GOL, MDI
 |
Crystal Structure Of C-Met Bound By Compound 1
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.75 Å Release Date: 2020-12-09 Classification: TRANSFERASE Ligands: SV5, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-12-09
Ligands: SV5, SO4
 |
Crystal Structure Of C-Met Bound By Compound 2
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.23 Å Release Date: 2020-12-09 Classification: TRANSFERASE Ligands: SVK, CL, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-12-09
Ligands: SVK, CL, SO4
 |
Crystal Structure Of C-Met Bound By Compound 3
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.93 Å Release Date: 2020-12-09 Classification: TRANSFERASE Ligands: SWB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-12-09
Ligands: SWB
 |
Crystal Structure Of C-Met Bound By Compound 4
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.02 Å Release Date: 2020-12-09 Classification: TRANSFERASE Ligands: EDO, SVH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-12-09
Ligands: EDO, SVH