Search Count: 53
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Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Indazole Inhibitor Compound 6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.31 Å Release Date: 2024-09-18 Classification: TRANSFERASE Ligands: A1AV4, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-09-18
Ligands: A1AV4, EDO
 |
Structure Of Compound 2 Bound To The Chk1 10-Point Mutant
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.76 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-11-01
Ligands: ZXH
 |
Structure Of Compound 5 Bound To The Chk1 10-Point Mutant
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.88 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-11-01
Ligands: ZXL
 |
Structure Of Compound 13 Bound To The Chk1 10-Point Mutant
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2023-11-01 Classification: TRANSFERASE Ligands: ZXP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-11-01
Ligands: ZXP
 |
Structure Of Lrrk2-Chk1 10-Pt. Mutant Complex With Heteroaryl-1H-Indazole Lrrk2 Inhibitor 14
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.49 Å Release Date: 2023-02-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: UUF |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-02-22
Ligands: UUF
 |
Structure Of Lrrk2-Chk1 10-Pt. Mutant Complex With Heteroaryl-1H-Indazole Lrrk2 Inhibitor 25
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2023-02-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: UU6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2023-02-22
Ligands: UU6
 |
Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Inhibitor 06
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.48 Å Release Date: 2022-01-12 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: BVI, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-12
Ligands: BVI, EDO
 |
Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Inhibitor 09
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.48 Å Release Date: 2022-01-12 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: BWI, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-12
Ligands: BWI, EDO
 |
Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Inhibitor 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.46 Å Release Date: 2022-01-12 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: BXI |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-12
Ligands: BXI
 |
Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Inhibitor 22
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.12 Å Release Date: 2022-01-12 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: L80 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-12
Ligands: L80
 |
Structure Of Chk1 10-Pt. Mutant Complex With Lrrk2 Inhibitor 24
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2022-01-12 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: BYL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-01-12
Ligands: BYL
 |
Discovery Of Mli-2, An Orally Available And Selective Lrrk2 Inhibitor That Reduces Brain Kinase Activity
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION Resolution:1.69 Å Release Date: 2017-03-15 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 81Y, SO4 |
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION
Release Date: 2017-03-15
Ligands: 81Y, SO4
 |
Bace1 In Complex With (S)-5-(3-Chloro-5-(5-(Prop-1-Yn-1-Yl)Pyridin-3-Yl)Thiophen-2-Yl)-2,5-Dimethyl-1,2,4-Thiadiazinan-3-Iminium 1,1-Dioxide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 66J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: 66J
 |
Bace1 In Complex With 4-(3-(Furan-2-Carboxamido)Phenyl)-1-Methyl-5-Oxo-4-Phenylimidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.83 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 66H |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: TLA, 66H
 |
Bace1 In Complex With (R)-N-(3-(3-Amino-2,5-Dimethyl-1,1-Dioxido-5,6-Dihydro-2H-1,2,4-Thiadiazin-5-Yl)-4-Fluorophenyl)-5-Fluoropicolinamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 66F |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: 66F
 |
Bace-1 In Complex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoropyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60Y
 |
Bace-1 Incomplex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoro-4-Methoxypyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60W
 |
Bace-1 Incomplex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60V, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60V, TLA
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(4-Ethoxy-5-Fluoro-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60U
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methyl-6-(Methylthio)Pyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.49 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 954 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 954