Search Count: 24
 |
Discovery Of Mli-2, An Orally Available And Selective Lrrk2 Inhibitor That Reduces Brain Kinase Activity
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION Resolution:1.69 Å Release Date: 2017-03-15 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 81Y, SO4 |
Organism: Rattus norvegicus
Method: X-RAY DIFFRACTION
Release Date: 2017-03-15
Ligands: 81Y, SO4
 |
Bace1 In Complex With (S)-5-(3-Chloro-5-(5-(Prop-1-Yn-1-Yl)Pyridin-3-Yl)Thiophen-2-Yl)-2,5-Dimethyl-1,2,4-Thiadiazinan-3-Iminium 1,1-Dioxide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.95 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 66J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: 66J
 |
Bace1 In Complex With 4-(3-(Furan-2-Carboxamido)Phenyl)-1-Methyl-5-Oxo-4-Phenylimidazolidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.83 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 66H |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: TLA, 66H
 |
Bace1 In Complex With (R)-N-(3-(3-Amino-2,5-Dimethyl-1,1-Dioxido-5,6-Dihydro-2H-1,2,4-Thiadiazin-5-Yl)-4-Fluorophenyl)-5-Fluoropicolinamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.50 Å Release Date: 2016-11-09 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 66F |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-11-09
Ligands: 66F
 |
Bace-1 In Complex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoropyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.65 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60Y |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60Y
 |
Bace-1 Incomplex With (7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-6-(5-Fluoro-4-Methoxypyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60W
 |
Bace-1 Incomplex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60V, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60V, TLA
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(4-Ethoxy-5-Fluoro-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60U |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60U
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methyl-6-(Methylthio)Pyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.49 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 954 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 954
 |
Bace-1 In Complex With (4Ar,7As)-7A-(2,6-Difluorophenyl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.53 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60T, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60T, TLA
 |
Bace-1 In Complex With (7Ar)-7A-(5-Cyanothiophen-2-Yl)-6-(5-Fluoro-4-Methyl-6-(Methylamino)Pyrimidin-2-Yl)-3-Methyl-4-Oxooctahydro-2H-Pyrrolo[3,4-D]Pyrimidin-2-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.55 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 60S |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: TLA, 60S
 |
Bace-1 In Complex With (4Ar,7As)-7A-(2,4-Difluorophenyl)-6-(5-Fluoro-4-Methoxy-6-Methylpyrimidin-2-Yl)-2-Imino-3-Methyloctahydro-4H-Pyrrolo[3,4-D]Pyrimidin-4-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.71 Å Release Date: 2016-03-16 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 60X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-03-16
Ligands: 60X
 |
Structure Of Bace Bound To 3-(5-((7Ar)-2-Imino-6-(6-Methoxypyridin-2-Yl)-3-Methyl-4-Oxooctahydro-1H-Pyrrolo[3,4-D]Pyrimidin-7A-Yl)Thiophen-3-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10O
 |
Structure Of Bace Bound To 2-((7Ar)-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-2-Imino-3-Methyl-4-Oxohexahydro-1H-Pyrrolo[3,4-D]Pyrimidin-6(2H)-Yl)Nicotinonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10Q |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10Q
 |
Structure Of Bace Bound To 3-(5-((7Ar)-2-Imino-6-(3-Methoxypyridin-2-Yl)-3-Methyl-4-Oxooctahydro-1H-Pyrrolo[3,4-D]Pyrimidin-7A-Yl)Thiophen-3-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.96 Å Release Date: 2012-11-07 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10V |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-11-07
Ligands: TLA, 10V
 |
Structure Of Bace-1 Bound To (7Ar)-6-Benzoyl-7A-(4-(3-Cyanophenyl)Thiophen-2-Yl)-3-Methyl-4-Oxohexahydro-1H-Pyrrolo[3,4-D]Pyrimidin-2(3H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2012-10-17 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 10J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-10-17
Ligands: 10J
 |
Structure Of Bace Bound To 2-Fluoro-5-(5-(2-Imino-3-Methyl-4-Oxo-6-Phenyloctahydro-1H-Pyrrolo[3,4-D]Pyrimidin-7A-Yl)Thiophen-2-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.60 Å Release Date: 2012-10-17 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 10W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-10-17
Ligands: TLA, 10W
 |
Structure Of Bace Bound To (S)-3-(5-(2-Imino-1,4-Dimethyl-6-Oxohexahydropyrimidin-4-Yl)Thiophen-3-Yl)Benzonitrile
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.83 Å Release Date: 2012-10-17 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: TLA, 13W |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-10-17
Ligands: TLA, 13W
 |
Structure Of Bace In Complex With (S)-4-(3-Chloro-5-(5-(Prop-1-Yn-1-Yl)Pyridin-3-Yl)Thiophen-2-Yl)-1,4-Dimethyl-6-Oxotetrahydropyrimidin-2(1H)-Iminium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.70 Å Release Date: 2012-08-08 Classification: Hydrolase/Hydrolase inhibitor Ligands: 0V6 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-08-08
Ligands: 0V6
 |
Structure Of Bace Bound To 2-Imino-3-Methyl-5,5-Diphenylimidazolidin-4-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2012-03-21 Classification: HYDROLASE/HYDROLASE INHIBITOR Ligands: 0KK, TLA |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2012-03-21
Ligands: 0KK, TLA