Search Count: 17
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Crystal Structure Of Menin In Complex With Inhibitor Compound 15
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVE
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Crystal Structure Of Menin In Complex With Inhibitor Compound 26
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVF, K, EPE, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVF, K, EPE, SO4
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Crystal Structure Of Menin In Complex With Inhibitor Compound 20
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.98 Å Release Date: 2025-01-15 Classification: PROTEIN BINDING/INHIBITOR Ligands: A1AVG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2025-01-15
Ligands: A1AVG
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Crystal Structure Of Non-Receptor Protein Tyrosine Phosphatase Shp2 In Complex With Inhibitor Compound 7
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2024-01-03 Classification: HYDROLASE/INHIBITOR Ligands: W8I |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-01-03
Ligands: W8I
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Crystal Structure Of Non-Receptor Protein Tyrosine Phosphatase Shp2 In Complex With Inhibitor Compound 24
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.06 Å Release Date: 2024-01-03 Classification: HYDROLASE/INHIBITOR Ligands: WAB |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2024-01-03
Ligands: WAB
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Kras G12D In Complex With Mrtx-1133
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.30 Å Release Date: 2021-12-22 Classification: Hydrolase/Hydrolase Inhibitor Ligands: GDP, 6IC, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 6IC, MG
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Crystal Structure Of Kras G12D With Compound 15 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.27 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7L8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7L8
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Crystal Structure Of Kras G12D With Compound 25 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2R,4R,7As)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.59 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7NL, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7NL, GOL, EDO
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Crystal Structure Of Kras G12D With Compound 24 (4-(4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-8-Fluoro-2-{[(2S,4S,7Ar)-2-Fluorotetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidin-7-Yl)Naphthalen-2-Ol) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.56 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7NZ, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7NZ, MG
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Kras G12D In Complex With Compound 5B (7-(8-Chloronaphthalen-1-Yl)-8-Fluoro-2-{[(2S)-1-Methylpyrrolidin-2-Yl]Methoxy}-4-(Piperazin-1-Yl)Pyrido[4,3-D]Pyrimidine)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.10 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, 7IZ, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, MG, 7IZ, GOL
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Crystal Structure Of Kras G12D With Compound 36 (4-[(1R,5S)-3,8-Diazabicyclo[3.2.1]Octan-3-Yl]-7-(8-Ethynyl-7-Fluoronaphthalen-1-Yl)-8-Fluoro-2-{[(4S,7As)-Tetrahydro-1H-Pyrrolizin-7A(5H)-Yl]Methoxy}Pyrido[4,3-D]Pyrimidine) Bound
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.29 Å Release Date: 2021-12-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, 7OE, MG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-12-22
Ligands: GDP, 7OE, MG
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Synthetic Glycoform Of Human Interleukin 6
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.00 Å Release Date: 2021-04-07 Classification: CYTOKINE |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-04-07
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.27 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1R |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1R
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.03 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, QH4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, QH4
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Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.94 Å Release Date: 2020-04-22 Classification: HYDROLASE/INHIBITOR Ligands: GDP, MG, M1X |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2020-04-22
Ligands: GDP, MG, M1X
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9M
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Tetrahydropyridopyrimidines As Covalent Inhibitors Of Kras-G12C
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.72 Å Release Date: 2018-12-12 Classification: ONCOPROTEIN Ligands: GDP, MG, K9J |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2018-12-12
Ligands: GDP, MG, K9J