Search Count: 9
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Complex With Compound 15 ((3'R)-1'-(5-Amino-1-Phenyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2026-04-01 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6X, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-04-01
Ligands: MES, A1C6X, NAG
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N-Alkyl & N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.78 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: A1C6O |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: A1C6O
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasmakallikrein Inhibitors Complex With Compound 4 ((3'R)-1'-(5-Amino-1-Benzyl-1H-Pyrazole-4-Carbonyl)-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Q, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Q, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 25 ((3'R)-1'-{(1P)-5-Amino-1-[2-(Trifluoromethoxy)Phenyl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.62 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C6Z, NAG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C6Z, NAG
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N-Alkyl &Amp; N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy To Identify Orally Bioavailable Plasma Kallikrein Inhibitors Compound 13 ((3'R)-1'-{5-Amino-1-[(2S)-1,1,1-Trifluorobutan-2-Yl]-1H-Pyrazole-4-Carbonyl}-6-Chloro-5-Fluorospiro[[3,1]Benzoxazine-4,3'-Piperidin]-2(1H)-One)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2026-03-11 Classification: HYDROLASE/INHIBITOR Ligands: MES, A1C7M |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2026-03-11
Ligands: MES, A1C7M
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Structure Of Human Sting In Complex With Mk-1454
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.32 Å Release Date: 2022-04-06 Classification: IMMUNE SYSTEM Ligands: ZEV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2022-04-06
Ligands: ZEV
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Prmt5:Mep50 Complexed With 5,5-Bicyclic Inhibitor Compound 4
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.52 Å Release Date: 2021-04-21 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: WFM, EDO, CL, PEG |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-04-21
Ligands: WFM, EDO, CL, PEG
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Prmt5:Mep50 Complexed With 5,5-Bicyclic Inhibitor Compound 34
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.43 Å Release Date: 2021-04-21 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: EDO, WFS |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-04-21
Ligands: EDO, WFS
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Prmt5:Mep50 Complexed With 5,5-Bicyclic Inhibitor Compound 72
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.50 Å Release Date: 2021-04-21 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: EDO, WFV |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-04-21
Ligands: EDO, WFV