Search Count: 31
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Crystal Structure Of Pi3Kalpha Selective Inhibitor Pf-06843195
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.41 Å Release Date: 2021-01-06 Classification: SIGNALING PROTEIN, Transferase Ligands: VXY |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-01-06
Ligands: VXY
 |
Crystal Structure Of Pi3Kalpha Selective Inhibitor 11-1575
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.77 Å Release Date: 2021-01-06 Classification: SIGNALING PROTEIN, Transferase Ligands: VY4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-01-06
Ligands: VY4
 |
Crystal Structure Of Pi3Kalpha Inhibitor 10-5429
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.74 Å Release Date: 2021-01-06 Classification: SIGNALING PROTEIN, Transferase Ligands: VY1 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-01-06
Ligands: VY1
 |
Crystal Structure Of Pi3Kalpha Inhibitor 4-0686
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.90 Å Release Date: 2021-01-06 Classification: SIGNALING PROTEIN, Transferase Ligands: VYP |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2021-01-06
Ligands: VYP
 |
Crystal Structure Of The Egfr Kinase Domain (L858R, T790M, V948R) In Complex With A Covalent Inhibitor N-[(3R,4R)-4-Fluoro-1-{6-[(1-Methyl-1H-Pyrazol-4-Yl)Amino]-9-(Propan-2-Yl)-9H-Purin-2-Yl}Pyrrolidin-3-Yl]Propanamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.46 Å Release Date: 2017-03-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 8BP, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-22
Ligands: 8BP, SO4, GOL
 |
Crystal Structure Of The Egfr Kinase Domain (L858R, T790M, V948R) In Complex With A Covalent Inhibitor N-[(3R,4R)-4-Fluoro-1-{6-[(3-Methoxy-1-Methyl-1H-Pyrazol-4-Yl)Amino]-9-(Propan-2-Yl)-9H-Purin-2-Yl}Pyrrolidin-3-Yl]Propanamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.33 Å Release Date: 2017-03-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 8AM, SO4, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-22
Ligands: 8AM, SO4, GOL, EDO
 |
Crystal Structure Of The Egfr Kinase Domain (L858R, T790M, V948R) In Complex With 4-(4-{[2-{[(3S)-1-Acetylpyrrolidin-3-Yl]Amino}-9-(Propan-2-Yl)-9H-Purin-6-Yl]Amino}Phenyl)-1-Methylpiperazin-1-Ium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.82 Å Release Date: 2017-03-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 8BM, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-22
Ligands: 8BM, SO4, GOL
 |
Crystal Structure Of The Egfr Kinase Domain In Complex With 4-(4-{[2-{[(3S)-1-Acetylpyrrolidin-3-Yl]Amino}-9-(Propan-2-Yl)-9H-Purin-6-Yl]Amino}Phenyl)-1-Methylpiperazin-1-Ium
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.53 Å Release Date: 2017-03-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 8BM |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-22
Ligands: 8BM
 |
Crystal Structure Of The Egfr Kinase Domain (L858R, T790M, V948R) In Complex With A Covalent Inhibitor N-[(3R,4R)-4-Fluoro-1-{6-[(3-Methoxy-1-Methyl-1H-Pyrazol-4-Yl)Amino]-9-Methyl-9H-Purin-2-Yl}Pyrrolidin-3-Yl]Propanamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.58 Å Release Date: 2017-03-22 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 8BS, SO4, GOL, EDO |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2017-03-22
Ligands: 8BS, SO4, GOL, EDO
 |
Structure Of Human Anaplastic Lymphoma Kinase In Complex With 2-[(1R)-1-{[2-Amino-5-(1,3-Dimethyl-1H-Pyrazol-4-Yl)Pyridin-3-Yl]Oxy}Ethyl]-4-Fluoro-N,N-Dimethylbenzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.30 Å Release Date: 2016-08-17 Classification: Transferase/Transferase Inhibitor Ligands: 6YL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-08-17
Ligands: 6YL
 |
Egfr (L858R, T790M, V948R) In Complex With N-{3-[(2-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Oxy]Phenyl}Prop-2-Enamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.52 Å Release Date: 2016-02-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 633, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-02-03
Ligands: 633, SO4, GOL
 |
Egfr (L858R, T790M, V948R) In Complex With N-[3-({2-[(1-Methyl-1H-Pyrazol-4-Yl)Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}Oxy)Phenyl]Prop-2-Enamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.42 Å Release Date: 2016-02-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 634, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-02-03
Ligands: 634, SO4, GOL
 |
Egfr (L858R, T790M, V948R) In Complex With 1-[(3R,4R)-3-[({2-[(1-Methyl-1H-Pyrazol-4-Yl)Amino]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl}Oxy)Methyl]-4-(Trifluoromethyl)Pyrrolidin-1-Yl]Prop-2-En-1-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.15 Å Release Date: 2016-02-03 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 63A, SO4, GOL |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-02-03
Ligands: 63A, SO4, GOL
 |
Egfr (L858R, T790M, V948R) In Complex With 1-{(3R,4R)-3-[5-Chloro-2-(1-Methyl-1H-Pyrazol-4-Ylamino)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yloxymethyl]-4-Methoxy-Pyrrolidin-1-Yl}Propenone (Pf-06459988)
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.85 Å Release Date: 2016-01-27 Classification: TRANSFERASE/TRANSFERASE INHIBITOR Ligands: 630, SO4 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2016-01-27
Ligands: 630, SO4
 |
Structure Of The Human Anaplastic Lymphoma Kinase In Complex With Pf- 06463922 ((10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl-15-Oxo-10,15,16, 17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo(4,3-H)(2,5,11) Benzoxadiazacyclotetradecine-3-Carbonitrile).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: 5P8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: 5P8
 |
Structure Of L1196M Mutant Human Anaplastic Lymphoma Kinase In Complex With Pf-06463922 ((10R)-7-Amino-12-Fluoro-2,10,16-Trimethyl- 15-Oxo-10,15,16,17-Tetrahydro-2H-8,4-(Metheno)Pyrazolo(4,3-H)(2,5,11) Benzoxadiazacyclotetradecine-3-Carbonitrile).
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.66 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: 5P8 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: 5P8
 |
Structure Of The Human Anaplastic Lymphoma Kinase In Complex With The Inhibitor 2-((1R)-1-((3-Amino-6-(2-Methoxypyridin-3-Yl)Pyrazin-2-Yl) Oxy)Ethyl)-4-Fluoro-N-Methylbenzamide
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:2.05 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: YPW |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: YPW
 |
Structure Of The Human Anaplastic Lymphoma Kinase In Complex With The Inhibitor 3-((1R)-1-(5-Fluoro-2-(2H-1,2,3-Triazol-2-Yl)Phenyl)Ethoxy)- 5-(3-(Methylsulfonyl)Phenyl)Pyridin-2-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.73 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: GWH |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: GWH
 |
Structure Of The Human Anaplastic Lymphoma Kinase In Complex With The Inhibitor (10R)-7-Amino-12-Fluoro-1,3,10,16-Tetramethyl-16,17-Dihydro- 1H-8,4-(Metheno)Pyrazolo(4,3-H)(2,5,11)Benzoxadiazacyclotetradecin-15(10H)-One
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.80 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: IV7 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: IV7
 |
Structure Of The Human Anaplastic Lymphoma Kinase In Complex With The Inhibitor 3-((1R)-1-(5-Fluoro-2-Methoxyphenyl)Ethoxy)-5-(1-Methyl-1H- 1,2,3-Triazol-5-Yl)Pyridin-2-Amine
Organism: Homo sapiens
Method: X-RAY DIFFRACTION Resolution:1.90 Å Release Date: 2014-05-28 Classification: TRANSFERASE Ligands: 3U9 |
Organism: Homo sapiens
Method: X-RAY DIFFRACTION
Release Date: 2014-05-28
Ligands: 3U9